The B side of rheumatoid arthritis pathogenesis

Stefano Alivernini, Elisa Gremese, Barbara Tolusso, Clara Di Mario, Gianfranco Ferraccioli, Anna Laura Fedele

Risultato della ricerca: Contributo in rivistaArticolo in rivista

4 Citazioni (Scopus)

Abstract

In the last years, a dramatic amount of research has been performedincreasing the knowledge about the biological mechanism underpinning Rheumatoid Arthritis (RA) inflammation, putting B lymphocytes in the center of RA pathogenesis. Nowadays, B cell phenotypes and autoantibodies positivity arose as important biomarkers in early and long-standing disease. Moreover, comparative analysis of peripheral blood and synovial tissue compartments enables the identification of novel physiopathological mechanisms promoting inflammation. In this narrative review we will discuss the biological relevance of B cell derived autoimmunity and in RA course, from disease onset to remission achievement.
Lingua originaleEnglish
pagine (da-a)104465-N/A
RivistaPharmacological Research
Volume149
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • Autoantibodies
  • B lymphocytes
  • Biomarkers
  • Peripheral Blood
  • Rheumatoid Arthritis
  • Synovial tissue

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