The Aurora A and B kinases are up-regulated in bone marrow-derived chronic lymphocytic leukemia cells and represent potential therapeutic targets

Luca Laurenti, F De Paula Careta, S Gobessi, Ra Panepucci, E Bojnik, F Morato De Oliveira, D Mazza Matos, Rp Falcão, Ma Zago, Dg Efremov

Risultato della ricerca: Contributo in rivistaArticolo in rivista

12 Citazioni (Scopus)

Abstract

The malignant B cells in chronic lymphocytic leukemia receive signals from the bone marrow and lymph node microenvironments which regulate their survival and proliferation. Characterization of these signals and the pathways that propagate them to the interior of the cell is important for the identification of novel potential targets for therapeutic intervention.
Lingua originaleEnglish
pagine (da-a)1246-1254
Numero di pagine9
RivistaHaematologica
Volume97
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • Animals
  • Antineoplastic Agents
  • Apoptosis
  • Bone Marrow Cells
  • Cell Cycle
  • Cell Line, Tumor
  • Cell Proliferation
  • Cluster Analysis
  • Female
  • Gene Expression Profiling
  • Gene Expression Regulation, Leukemic
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Mice
  • Mitosis
  • Piperazines
  • Protein-Serine-Threonine Kinases
  • Up-Regulation

Fingerprint Entra nei temi di ricerca di 'The Aurora A and B kinases are up-regulated in bone marrow-derived chronic lymphocytic leukemia cells and represent potential therapeutic targets'. Insieme formano una fingerprint unica.

Cita questo