The ATI score (age-thrombus burden-index of microcirculatory resistance) determined during primary percutaneous coronary intervention predicts final infarct size in patients with ST-elevation myocardial infarction: A cardiac magnetic resonance validation study

Giovanni Luigi De Maria; Mohammad Alkhalil; Mathias Wolfrum; Gregor Fahrni; Alessandra Borlotti; Lisa Gaughran; Sam Dawkins; Jeremy P. Langrish; Andrew J. Lucking; Robin P. Choudhury; Italo Porto; Filippo Crea; Erica Dall'Armellina; Keith M. Channon; Rajesh K. Kharbanda; Adrian P. Banning

doi:10.4244/EIJ-D-17-00367

The ATI score (age-thrombus burden-index of microcirculatory resistance) determined during primary percutaneous coronary intervention predicts final infarct size in patients with ST-elevation myocardial infarction: A cardiac magnetic resonance validation study

Giovanni Luigi De Maria, Mohammad Alkhalil, Mathias Wolfrum, Gregor Fahrni, Alessandra Borlotti, Lisa Gaughran, Sam Dawkins, Jeremy P. Langrish, Andrew J. Lucking, Robin P. Choudhury, Italo Porto, Filippo Crea, Erica Dall'Armellina, Keith M. Channon, Rajesh K. Kharbanda, Adrian P. Banning

Risultato della ricerca: Contributo in rivista › Articolo in rivista

17 Citazioni (Scopus)

Abstract

AIMS: The age-thrombus burden-index of microcirculatory resistance (ATI) score is a diagnostic tool able to predict suboptimal myocardial reperfusion before stenting, in patients with ST-elevation myocardial infarction (STEMI). We aimed to validate the ATI score against cardiac magnetic resonance imaging (cMRI). METHODS AND RESULTS: The ATI score was calculated prospectively in 80 STEMI patients. cMRI was performed within 48 hours in all patients and in 50 patients at six-month follow-up to assess the extent of infarct size (IS%) and microvascular obstruction (MVO%). The ATI score was calculated using age (>50=1 point), pre-stenting index of microcirculatory resistance (IMR) (>40 and <100=1 point; ≥100=2 points) and angiographic thrombus score (4=1 point; 5=3 points). ATI score was closely related to final IS% (ATI. Comment in Resistance to flow in the coronary microcirculation - we can measure it but what does it mean?

Lingua originale	English
pagine (da-a)	935-943
Numero di pagine	9
Rivista	EuroIntervention
Volume	13
DOI	https://doi.org/10.4244/EIJ-D-17-00367
Stato di pubblicazione	Pubblicato - 2017

Keywords

Aged
Aged, 80 and over
Coronary Circulation
Female
Humans
Magnetic Resonance Imaging
Male
Microcirculation
Middle Aged
Myocardial Infarction
Myocardial Reperfusion
Percutaneous Coronary Intervention
ST Elevation Myocardial Infarction
Treatment Outcome

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10.4244/EIJ-D-17-00367

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De Maria, G. L., Alkhalil, M., Wolfrum, M., Fahrni, G., Borlotti, A., Gaughran, L., Dawkins, S., Langrish, J. P., Lucking, A. J., Choudhury, R. P., Porto, I., Crea, F., Dall'Armellina, E., Channon, K. M., Kharbanda, R. K., & Banning, A. P. (2017). The ATI score (age-thrombus burden-index of microcirculatory resistance) determined during primary percutaneous coronary intervention predicts final infarct size in patients with ST-elevation myocardial infarction: A cardiac magnetic resonance validation study. EuroIntervention, 13, 935-943. https://doi.org/10.4244/EIJ-D-17-00367

De Maria, Giovanni Luigi ; Alkhalil, Mohammad ; Wolfrum, Mathias et al. / The ATI score (age-thrombus burden-index of microcirculatory resistance) determined during primary percutaneous coronary intervention predicts final infarct size in patients with ST-elevation myocardial infarction: A cardiac magnetic resonance validation study. In: EuroIntervention. 2017 ; Vol. 13. pagg. 935-943.

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title = "The ATI score (age-thrombus burden-index of microcirculatory resistance) determined during primary percutaneous coronary intervention predicts final infarct size in patients with ST-elevation myocardial infarction: A cardiac magnetic resonance validation study",

abstract = "AIMS: The age-thrombus burden-index of microcirculatory resistance (ATI) score is a diagnostic tool able to predict suboptimal myocardial reperfusion before stenting, in patients with ST-elevation myocardial infarction (STEMI). We aimed to validate the ATI score against cardiac magnetic resonance imaging (cMRI). METHODS AND RESULTS: The ATI score was calculated prospectively in 80 STEMI patients. cMRI was performed within 48 hours in all patients and in 50 patients at six-month follow-up to assess the extent of infarct size (IS%) and microvascular obstruction (MVO%). The ATI score was calculated using age (>50=1 point), pre-stenting index of microcirculatory resistance (IMR) (>40 and <100=1 point; ≥100=2 points) and angiographic thrombus score (4=1 point; 5=3 points). ATI score was closely related to final IS% (ATI. Comment in Resistance to flow in the coronary microcirculation - we can measure it but what does it mean?",

keywords = "Aged, Aged, 80 and over, Coronary Circulation, Female, Humans, Magnetic Resonance Imaging, Male, Microcirculation, Middle Aged, Myocardial Infarction, Myocardial Reperfusion, Percutaneous Coronary Intervention, ST Elevation Myocardial Infarction, Treatment Outcome, Aged, Aged, 80 and over, Coronary Circulation, Female, Humans, Magnetic Resonance Imaging, Male, Microcirculation, Middle Aged, Myocardial Infarction, Myocardial Reperfusion, Percutaneous Coronary Intervention, ST Elevation Myocardial Infarction, Treatment Outcome",

author = "{De Maria}, {Giovanni Luigi} and Mohammad Alkhalil and Mathias Wolfrum and Gregor Fahrni and Alessandra Borlotti and Lisa Gaughran and Sam Dawkins and Langrish, {Jeremy P.} and Lucking, {Andrew J.} and Choudhury, {Robin P.} and Italo Porto and Filippo Crea and Erica Dall'Armellina and Channon, {Keith M.} and Kharbanda, {Rajesh K.} and Banning, {Adrian P.}",

year = "2017",

doi = "10.4244/EIJ-D-17-00367",

language = "English",

volume = "13",

pages = "935--943",

journal = "EuroIntervention",

issn = "1774-024X",

publisher = "Europa Group",

}

De Maria, GL, Alkhalil, M, Wolfrum, M, Fahrni, G, Borlotti, A, Gaughran, L, Dawkins, S, Langrish, JP, Lucking, AJ, Choudhury, RP, Porto, I, Crea, F, Dall'Armellina, E, Channon, KM, Kharbanda, RK & Banning, AP 2017, 'The ATI score (age-thrombus burden-index of microcirculatory resistance) determined during primary percutaneous coronary intervention predicts final infarct size in patients with ST-elevation myocardial infarction: A cardiac magnetic resonance validation study', EuroIntervention, vol. 13, pagg. 935-943. https://doi.org/10.4244/EIJ-D-17-00367

The ATI score (age-thrombus burden-index of microcirculatory resistance) determined during primary percutaneous coronary intervention predicts final infarct size in patients with ST-elevation myocardial infarction: A cardiac magnetic resonance validation study. / De Maria, Giovanni Luigi; Alkhalil, Mohammad; Wolfrum, Mathias et al.
In: EuroIntervention, Vol. 13, 2017, pag. 935-943.

Risultato della ricerca: Contributo in rivista › Articolo in rivista

TY - JOUR

T1 - The ATI score (age-thrombus burden-index of microcirculatory resistance) determined during primary percutaneous coronary intervention predicts final infarct size in patients with ST-elevation myocardial infarction: A cardiac magnetic resonance validation study

AU - De Maria, Giovanni Luigi

AU - Alkhalil, Mohammad

AU - Wolfrum, Mathias

AU - Fahrni, Gregor

AU - Borlotti, Alessandra

AU - Gaughran, Lisa

AU - Dawkins, Sam

AU - Langrish, Jeremy P.

AU - Lucking, Andrew J.

AU - Choudhury, Robin P.

AU - Porto, Italo

AU - Crea, Filippo

AU - Dall'Armellina, Erica

AU - Channon, Keith M.

AU - Kharbanda, Rajesh K.

AU - Banning, Adrian P.

PY - 2017

Y1 - 2017

N2 - AIMS: The age-thrombus burden-index of microcirculatory resistance (ATI) score is a diagnostic tool able to predict suboptimal myocardial reperfusion before stenting, in patients with ST-elevation myocardial infarction (STEMI). We aimed to validate the ATI score against cardiac magnetic resonance imaging (cMRI). METHODS AND RESULTS: The ATI score was calculated prospectively in 80 STEMI patients. cMRI was performed within 48 hours in all patients and in 50 patients at six-month follow-up to assess the extent of infarct size (IS%) and microvascular obstruction (MVO%). The ATI score was calculated using age (>50=1 point), pre-stenting index of microcirculatory resistance (IMR) (>40 and <100=1 point; ≥100=2 points) and angiographic thrombus score (4=1 point; 5=3 points). ATI score was closely related to final IS% (ATI. Comment in Resistance to flow in the coronary microcirculation - we can measure it but what does it mean?

AB - AIMS: The age-thrombus burden-index of microcirculatory resistance (ATI) score is a diagnostic tool able to predict suboptimal myocardial reperfusion before stenting, in patients with ST-elevation myocardial infarction (STEMI). We aimed to validate the ATI score against cardiac magnetic resonance imaging (cMRI). METHODS AND RESULTS: The ATI score was calculated prospectively in 80 STEMI patients. cMRI was performed within 48 hours in all patients and in 50 patients at six-month follow-up to assess the extent of infarct size (IS%) and microvascular obstruction (MVO%). The ATI score was calculated using age (>50=1 point), pre-stenting index of microcirculatory resistance (IMR) (>40 and <100=1 point; ≥100=2 points) and angiographic thrombus score (4=1 point; 5=3 points). ATI score was closely related to final IS% (ATI. Comment in Resistance to flow in the coronary microcirculation - we can measure it but what does it mean?

KW - Aged

KW - Aged, 80 and over

KW - Coronary Circulation

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Microcirculation

KW - Middle Aged

KW - Myocardial Infarction

KW - Myocardial Reperfusion

KW - Percutaneous Coronary Intervention

KW - ST Elevation Myocardial Infarction

KW - Treatment Outcome

KW - Aged

KW - Aged, 80 and over

KW - Coronary Circulation

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Microcirculation

KW - Middle Aged

KW - Myocardial Infarction

KW - Myocardial Reperfusion

KW - Percutaneous Coronary Intervention

KW - ST Elevation Myocardial Infarction

KW - Treatment Outcome

UR - http://hdl.handle.net/10807/126408

U2 - 10.4244/EIJ-D-17-00367

DO - 10.4244/EIJ-D-17-00367

M3 - Article

SN - 1774-024X

VL - 13

SP - 935

EP - 943

JO - EuroIntervention

JF - EuroIntervention

ER -

De Maria GL, Alkhalil M, Wolfrum M, Fahrni G, Borlotti A, Gaughran L et al. The ATI score (age-thrombus burden-index of microcirculatory resistance) determined during primary percutaneous coronary intervention predicts final infarct size in patients with ST-elevation myocardial infarction: A cardiac magnetic resonance validation study. EuroIntervention. 2017;13:935-943. doi: 10.4244/EIJ-D-17-00367