@article{539bee99f22746ab817349d3cb949eae,
title = "The association between delirium and sarcopenia in older adult patients admitted to acute geriatrics units: Results from the GLISTEN multicenter observational study",
abstract = "Background & aims: To date, studies assessing the relationship between sarcopenia and delirium, two of the most common geriatric syndromes, are lacking. We sought to explore this association by investigating the co-occurrence of these two conditions and the independent association between them in a population of hospitalized older adults. Methods: Cross-sectional multicenter analysis of older adults consecutively admitted to 12 acute geriatric units (AGUs). Sarcopenia was assessed upon admission by evaluating the presence of low skeletal mass index (kg/m2), and either low handgrip strength or low walking speed (European Working Group on Sarcopenia in Older People, EWGSOP criteria). Skeletal muscle mass was estimated using bioimpedance analysis. Participants underwent a comprehensive geriatric assessment upon admission; information concerning demographics, cognition (Short Portable Status Mental Questionnaire, SPMSQ) functional (Instrumental Activities of Daily Living, IADL and Basic-Activities of Daily Living, BADL), and health status (Charlson Index and specific diseases) was evaluated. The presence of delirium upon admission was ascertained as an explicit clinical diagnosis recorded by the researcher of each centre on the data form. All association estimates were reported as Prevalence Ratios (PRs) and 95% confidence intervals (CIs), using a Cox hazard proportional regression model with robust variance and constant time. Results: Of the 588 analyzed patients (mean age = 80.9 ± 6.8, 53.2% females), 199 (33.8%) had sarcopenia upon admission to the AGU. According to a multivariable Cox regression, delirium upon admission (PR 1.66, 95% CI: 1.12-2.45), IADL total score (PR 0.93, 95% CI: 0.87-0.98), Body Mass Index values (BMI) ranging from 18.5 to 25.0 (PR 1.70, 95% CI: 1.33-2.18), BMI values >18.5 (PR 2.53, 95% CI: 1.81-3.53), previous stroke (PR 1.51, 95% CI: 1.10-2.07) and chronic heart failure (CHF) (PR 1.31, 95% CI: 1.02-1.68) were significantly and independently associated with sarcopenia upon admission to the AGU. Conclusion: The study, carried out in a population of hospitalized older patients, shows that a diagnosis of delirium upon admission to the AGU was more frequent in those with sarcopenia than in others. Furthermore, the study found that delirium was independently associated with the risk of being sarcopenic upon admission to the AGU. Future studies are needed to confirm this association.",
keywords = "Body mass index, Critical Care and Intensive Care Medicine, Delirium, Elderly, Hospital, IADL, Nutrition and Dietetics, Sarcopenia, Body mass index, Critical Care and Intensive Care Medicine, Delirium, Elderly, Hospital, IADL, Nutrition and Dietetics, Sarcopenia",
author = "Francesco Landi and Giuseppe Bellelli and Antonella Zambon and Stefano Volpato and Pasquale Abete and Lara Bianchi and Mario Bo and Antonio Cherubini and Francesco Corica and {Di Bari}, Mauro and Marcello Maggio and Manca, {Giovanna Maria} and Rizzo, {Maria Rosaria} and Andrea Rossi and Gloria Brombo and Beatrice Ortolani and Elisabetta Savino and Elisa Maietti and Alberto Fisichella and Valeria Butt{\`o} and Mauro Zamboni and Cesare Caliari and Elena Ferrari and Francesco Orso and Flavia Sacco and {Di Meo}, {Maria Laura} and Francesca Pittella and Marco Motta and Francesca Massariello and Sergio Fusco and Roberto Schepisi and Christian Ferro and Lorenzo Marchese and Luca Agosta and Claudia Basile and Carla Coppola and Dalise, {Anna Maria} and Ilaria Fava and Olga Catte and Maura Orru and Paolo Salaris and Giuseppina Dell'Aquila and Barbara Carrieri",
year = "2017",
doi = "10.1016/j.clnu.2017.08.027",
language = "English",
pages = "1715--1722",
journal = "Clinical Nutrition",
issn = "0261-5614",
publisher = "Editori indicati : CHURCHILL LIVINGSTONE, JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH, SCOTLAND, MIDLOTHIAN, EH1 3AF Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010",
}