The anorexigenic peptide neurotensin relates to insulin sensitivity in obese patients after BPD or RYGB metabolic surgery

Geltrude Mingrone, Christian Von Loeffelholz, Lidia Castagneto Gissey, Tina Schumann, Christine Henke, Anica Kurzbach, Joachim Struck, Andreas Bergmann, Markolf Hanefeld, Ulrike Schatz, Giovanni Casella, Andreas L. Birkenfeld

Risultato della ricerca: Contributo in rivistaArticolo in rivista

6 Citazioni (Scopus)

Abstract

Neurotensin is a peptide with effects on appetite and intestinal lipid absorption. Experimental data suggest a role in glucose homeostasis, while human data is missing. Here, 20 morbidly obese subjects either underwent biliopancreatic diversion with duodenal switch (BPD), or Roux-en-Y gastric bypass (RYGB) in a randomized fashion. Before and 1 year after surgery, anthropometric data, body composition, clinical biochemistry, insulin sensitivity by means of euglycemic hyperinsulinemic clamps (HEC) and fasting plasma proneurotensin 1–117 were analyzed. Plasma proneurotensin increased significantly more 1 year after BDP than RYGB (P = 0.028), while weight loss was comparable. After metabolic surgery, proneurotensin correlated positively with insulin sensitivity (M-value) (r = 0.55, P < 0.001), while an inverse relationship with fasting glucose, HOMA-IR and HbA1c was observed (P < 0.05 for all components). After adjustment for age and gender, proneurotensin and BMI remained independently related with delta of M-value (β = 0.46 and β = 0.51, P < 0.05, resp.). From these data we conclude that proneurotensin positively correlates with insulin sensitivity uniquely after weight loss induced by metabolic surgery in humans. BDP leads to a stronger increase in the anorexigenic peptide compared to RYGB.
Lingua originaleEnglish
pagine (da-a)1-5
Numero di pagine5
RivistaInternational Journal of Obesity
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • Endocrinology, Diabetes and Metabolism
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Fingerprint Entra nei temi di ricerca di 'The anorexigenic peptide neurotensin relates to insulin sensitivity in obese patients after BPD or RYGB metabolic surgery'. Insieme formano una fingerprint unica.

Cita questo