The analgesic agent tapentadol inhibits calcitonin gene-related peptide release from isolated rat brainstem via a serotonergic mechanism

Maria Cristina Greco; Pierluigi Navarra; Giuseppe Tringali

doi:10.1016/j.lfs.2015.12.032

The analgesic agent tapentadol inhibits calcitonin gene-related peptide release from isolated rat brainstem via a serotonergic mechanism

Maria Cristina Greco
, Pierluigi Navarra^*
, Giuseppe Tringali

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

In this study we tested the hypothesis that tapentadol inhibits GGRP release from the rat brainstem through a mechanism mediated by the inhibition of NA reuptake; as a second alternative hypothesis, we investigated whether tapentadol inhibits GGRP release via the inhibition of 5-HT reuptake.

Lingua originale	Inglese
pagine (da-a)	N/A-N/A
Rivista	Life Sciences
Numero di pubblicazione	N/A
DOI	https://doi.org/10.1016/j.lfs.2015.12.032
Stato di pubblicazione	Pubblicato - 2015

All Science Journal Classification (ASJC) codes

Biochimica, Genetica, Biologia Molecolare Generali
Farmacologia, Tossicologia e Farmaceutica Generali

Keywords

5-hydroxytryptamine
Brainstem
Calcitonin gene-related peptide
Ondansetron
Rat
Tapentadol

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10.1016/j.lfs.2015.12.032

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KW - Brainstem

KW - Calcitonin gene-related peptide

KW - Ondansetron

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KW - Brainstem

KW - Calcitonin gene-related peptide

KW - Ondansetron

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The analgesic agent tapentadol inhibits calcitonin gene-related peptide release from isolated rat brainstem via a serotonergic mechanism

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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