The analgesic agent tapentadol inhibits calcitonin gene-related peptide release from isolated rat brainstem via a serotonergic mechanism

Maria Cristina Greco; Pierluigi Navarra; Giuseppe Tringali

doi:10.1016/j.lfs.2015.12.032

The analgesic agent tapentadol inhibits calcitonin gene-related peptide release from isolated rat brainstem via a serotonergic mechanism

Maria Cristina Greco, Pierluigi Navarra, Giuseppe Tringali

Risultato della ricerca: Contributo in rivista › Articolo in rivista

5 Citazioni (Scopus)

Abstract

In this study we tested the hypothesis that tapentadol inhibits GGRP release from the rat brainstem through a mechanism mediated by the inhibition of NA reuptake; as a second alternative hypothesis, we investigated whether tapentadol inhibits GGRP release via the inhibition of 5-HT reuptake.

Lingua originale	English
pagine (da-a)	N/A-N/A
Rivista	Life Sciences
DOI	https://doi.org/10.1016/j.lfs.2015.12.032
Stato di pubblicazione	Pubblicato - 2015

Keywords

5-hydroxytryptamine
Brainstem
Calcitonin gene-related peptide
Ondansetron
Rat
Tapentadol

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10.1016/j.lfs.2015.12.032

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title = "The analgesic agent tapentadol inhibits calcitonin gene-related peptide release from isolated rat brainstem via a serotonergic mechanism",

abstract = "In this study we tested the hypothesis that tapentadol inhibits GGRP release from the rat brainstem through a mechanism mediated by the inhibition of NA reuptake; as a second alternative hypothesis, we investigated whether tapentadol inhibits GGRP release via the inhibition of 5-HT reuptake.",

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AU - Greco, Maria Cristina

AU - Navarra, Pierluigi

AU - Tringali, Giuseppe

PY - 2015

Y1 - 2015

N2 - In this study we tested the hypothesis that tapentadol inhibits GGRP release from the rat brainstem through a mechanism mediated by the inhibition of NA reuptake; as a second alternative hypothesis, we investigated whether tapentadol inhibits GGRP release via the inhibition of 5-HT reuptake.

AB - In this study we tested the hypothesis that tapentadol inhibits GGRP release from the rat brainstem through a mechanism mediated by the inhibition of NA reuptake; as a second alternative hypothesis, we investigated whether tapentadol inhibits GGRP release via the inhibition of 5-HT reuptake.

KW - 5-hydroxytryptamine

KW - Brainstem

KW - Calcitonin gene-related peptide

KW - Ondansetron

KW - Rat

KW - Tapentadol

KW - 5-hydroxytryptamine

KW - Brainstem

KW - Calcitonin gene-related peptide

KW - Ondansetron

KW - Rat

KW - Tapentadol

UR - http://hdl.handle.net/10807/70698

U2 - 10.1016/j.lfs.2015.12.032

DO - 10.1016/j.lfs.2015.12.032

M3 - Article

SN - 0024-3205

SP - N/A-N/A

JO - Life Sciences

JF - Life Sciences

ER -

The analgesic agent tapentadol inhibits calcitonin gene-related peptide release from isolated rat brainstem via a serotonergic mechanism

Abstract

Keywords

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