The 9p21 Rs 1333040 polymorphism is associated with coronary microvascular obstruction in ST-segment elevation myocardial infarction treated by primary angioplasty

Antonino Buffon, Paolo Tondi, Roberto Pola, Filippo Crea, Francesco Fracassi, Giampaolo Niccoli, Vincenzo Vetrugno, Michele Cauteruccio, Ilaria Gatto, Igor Giarretta

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

Background: Microvascular obstruction (MVO) after primary percutaneous coronary intervention (pPCI) leads to higher incidence of both early and late complications. A number of single nucleotide polymorphisms in 9p21 chromosome have been shown to affect angiogenesis in response to ischaemia. In particular, Rs1333040 with its three genotypic vriants C/C, T/C and T/T might influence the occurrence of MVO after pPCI. Methods: We enrolled ST-elevation myocardial infarction (STEMI) patients undergoing pPCI. The Rs1333040 polymorphism was evaluated by polymerase chain reaction-restriction fragment length polymorphism using restriction endonucleases (Bsml). Two expert operators unaware of the patients' identity performed the angiographic analysis; collaterals were assessed applying Rentrop's classification. Angiographic MVO was defined as a post-pPCI Thrombolysis In Myocardial Infarction (TIMI)<3 or TIMI 3 with myocardial blush grade 0 or 1, whereas electrocardiographic MVO was defined as ST segment resolution Results: Among our 133 STEMI patients (mean age 63 +/- 11 years, men 72%), 35 (26%) and 53 (40%) respectively experienced angiographic or electrocardiographic MVO. Angiographic and electrocardiographic MVO were different among the three variants (p= 0.03 and p=0.02 respectively). In particular, T/T genotype was associated with a higher incidence of both angiographic and electrocardiographic MVO compared with C/C genotype (p=0.04 and p=0.03 respectively). Moreover, Rentrop score <2 detection rate differed among the three genotypes (p=0.03). In particular T/T genotype was associated with a higher incidence of a Rentrop score <2 as compared with C/C genotype (p= 0.02). Conclusion: Rs1333040 polymorphism genetic variants portend different MVO incidence. In particular, T/T genotype is related to angiographic and electrocardiographic MVO and to worse collaterals towards the culprit artery.
Lingua originaleEnglish
pagine (da-a)703-707-707
RivistaEUROPEAN HEART JOURNAL. ACUTE CARDIOVASCULAR CARE
Volume8
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • 9p21 polymorphism
  • Acute Coronary Syndrome
  • Aged
  • Angioplasty
  • Chromosomes, Human, Pair 9
  • Coronary Angiography
  • Coronary Occlusion
  • Coronary Vessels
  • Cyclin-Dependent Kinase Inhibitor p21
  • Electrocardiography
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Incidence
  • Male
  • Microcirculation
  • Middle Aged
  • Myocardial Infarction
  • Neovascularization, Physiologic
  • Percutaneous Coronary Intervention
  • Polymorphism, Single Nucleotide
  • Rs 1333040
  • ST Elevation Myocardial Infarction
  • ST-segment elevation myocardial infarction
  • Thrombolytic Therapy
  • acute coronary syndromes
  • microvascular obstruction
  • primary percutaneous coronary intervention

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