Thalamic dysfunction in schizophrenia suggested by whole-night deficits in slow and fast spindles

Fabio Ferrarelli, Pietro Bria, Mj Peterson, S Sarasso, Ba Riedner, Mj Murphy, Rm Benca, Nh Kalin, G. Tononi

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

Slow waves and sleep spindles are the two main oscillations occurring during non-REM sleep. While slow oscillations are primarily generated and modulated by the cortex, sleep spindles are initiated by the thalamic reticular nucleus and regulated by thalamo-reticular and thalamo-cortical circuits. In a recent high-density EEG study, the authors found that 18 medicated schizophrenia patients had reduced sleep spindles, compared with healthy and depressed subjects, during the first non-REM episode. In the present study, the authors investigated whether spindle deficits were present in a larger sample of schizophrenia patients, were consistent across the night, were related to antipsychotic medications, and were suggestive of impairments in specific neuronal circuits.
Lingua originaleEnglish
pagine (da-a)1339-1348
Numero di pagine10
RivistaTHE AMERICAN JOURNAL OF PSYCHIATRY
Volume167
DOI
Stato di pubblicazionePubblicato - 2010

Keywords

  • Adolescent
  • Adult
  • Antipsychotic Agents
  • Brain Mapping
  • Cerebral Cortex
  • Electroencephalography
  • Evoked Potentials
  • Female
  • Humans
  • Intralaminar Thalamic Nuclei
  • Male
  • Middle Aged
  • Nerve Net
  • Psychiatric Status Rating Scales
  • Reference Values
  • Schizophrenia
  • Schizophrenic Psychology
  • Signal Processing, Computer-Assisted
  • Sleep
  • Thalamus
  • Young Adult

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