TGF-β1 and IL-10 modulate IL-1β-induced membrane and soluble ICAM-1 in human myoblasts

Mariapaola Marino, Flavia Scuderi, Emanuela Bartoccioni

Risultato della ricerca: Contributo in rivistaArticolo in rivista

17 Citazioni (Scopus)

Abstract

We have previously shown that interleukin (IL)-1β and other inflammatory cytokines are able to induce the expression of membrane and soluble intercellular adhesion molecule (ICAM)-1 on human myoblasts. In this paper we found that IL-10 and transforming growth factor (TGF)-β1 are able to prevent IL-1β-induced membrane and soluble ICAM-1 protein expression on human myoblasts, with different time courses. The effect of both cytokines is associated to a reduction in ICAM-1 mRNA. Our findings suggest that IL-10 and TGF-β1 are able to influence the inflammatory process in muscle tissue at least in part by means of control of membrane and soluble ICAM-1. © 2002 Elsevier Science B.V. All rights reserved.
Lingua originaleEnglish
pagine (da-a)151-157
Numero di pagine7
RivistaJournal of Neuroimmunology
Volume134
DOI
Stato di pubblicazionePubblicato - 2003

Keywords

  • Cell Membrane
  • Cells, Cultured
  • Down-Regulation
  • Graft Rejection
  • Human myoblast
  • Humans
  • Intercellular Adhesion Molecule-1
  • Intercellular adhesion molecule-1 (ICAM-1)
  • Interleukin-1
  • Interleukin-1 (IL-1)
  • Interleukin-10
  • Interleukin-10 (IL-10)
  • Muscle
  • Muscle Cells
  • Muscle, Skeletal
  • Myoblasts, Skeletal
  • Myositis
  • RNA, Messenger
  • Reaction Time
  • Transforming Growth Factor beta
  • Transforming Growth Factor beta1
  • Transforming growth factor-β (TGF-β)

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