TY - JOUR
T1 - TGF-β1 and IL-10 modulate IL-1β-induced membrane and soluble ICAM-1 in human myoblasts
AU - Marino, Mariapaola
AU - Scuderi, F.
AU - Mannella, F.
AU - Bartoccioni, E.
PY - 2003
Y1 - 2003
N2 - We have previously shown that interleukin (IL)-1β and other inflammatory cytokines are able to induce the expression of membrane and soluble intercellular adhesion molecule (ICAM)-1 on human myoblasts. In this paper we found that IL-10 and transforming growth factor (TGF)-β1 are able to prevent IL-1β-induced membrane and soluble ICAM-1 protein expression on human myoblasts, with different time courses. The effect of both cytokines is associated to a reduction in ICAM-1 mRNA. Our findings suggest that IL-10 and TGF-β1 are able to influence the inflammatory process in muscle tissue at least in part by means of control of membrane and soluble ICAM-1. © 2002 Elsevier Science B.V. All rights reserved.
AB - We have previously shown that interleukin (IL)-1β and other inflammatory cytokines are able to induce the expression of membrane and soluble intercellular adhesion molecule (ICAM)-1 on human myoblasts. In this paper we found that IL-10 and transforming growth factor (TGF)-β1 are able to prevent IL-1β-induced membrane and soluble ICAM-1 protein expression on human myoblasts, with different time courses. The effect of both cytokines is associated to a reduction in ICAM-1 mRNA. Our findings suggest that IL-10 and TGF-β1 are able to influence the inflammatory process in muscle tissue at least in part by means of control of membrane and soluble ICAM-1. © 2002 Elsevier Science B.V. All rights reserved.
KW - Human myoblast
KW - Intercellular adhesion molecule-1 (ICAM-1)
KW - Interleukin-1 (IL-1)
KW - Interleukin-10 (IL-10)
KW - Muscle
KW - Transforming growth factor-β (TGF-β)
KW - Human myoblast
KW - Intercellular adhesion molecule-1 (ICAM-1)
KW - Interleukin-1 (IL-1)
KW - Interleukin-10 (IL-10)
KW - Muscle
KW - Transforming growth factor-β (TGF-β)
UR - https://publicatt.unicatt.it/handle/10807/145079
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=0037222149&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0037222149&origin=inward
U2 - 10.1016/S0165-5728(02)00399-5
DO - 10.1016/S0165-5728(02)00399-5
M3 - Article
SN - 0165-5728
VL - 134
SP - 151
EP - 157
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -