Preliminary Analysis of the Impact of COVID-19 Outbreak on Italian Liver Transplant Programs.

Liver Transplant Programs in Italy have faced a sequela of management and clinical decisionmaking\r\nproblems due to the high incidence in some regions of the country of severe acute\r\nrespiratory syndrome Coronavirus 2 (SARS-CoV-2). The Italian Society for Organ\r\nTransplantation (SITO) and the Board of Liver Transplant Program Directors issued a survey to\r\nassess the initial impact of this pandemic event on the routine activity of 22 Italian Liver\r\nTransplant Programs. One hundred percent of participants completed the survey within a few\r\ndays. The analysis is presented dividing the centers in two macro-areas: north-central Italy and\r\nsouth-central Italy. The reason for this is that the two areas had a different incidence of the\r\ninfection and because they have distinctive rates of cadaveric donation. Overall, all centers\r\nremained open although a reduction in the activity was noted. Transplant Programs reduced their\r\noutpatient activity both in terms of pre-transplant evaluation (68% of the centers) and transplant\r\nrecipient follow-up (100%); a reduction in transplant activity was observed in the first two weeks\r\nof March only in the north-central macro area (23 LTs vs 39 in 2018 and 60 in 2019); overall,\r\nSARS-CoV-2 infection was registered for 24 liver transplant recipients and 37 health care\r\nproviders in liver transplant units. In the perspective of the increasing magnitude of the epidemic,\r\nmore data will be required to define appropriate strategies for the increasingly complex\r\nmanagement of liver transplant patients.