Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis

Gianluca Svegliati-Baroni; Stefania Saccomanno; Sabina Saccomanno; Chiara Rychlicki; Laura Agostinelli; Samuele De Minicis; Cinzia Candelaresi; Graziella Faraci; Deborah Pacetti; Marco Vivarelli; Daniele Nicolini; Paolo Garelli; Alessandro Casini; Melania Manco; Geltrude Mingrone; Andrea Risaliti; Giuseppe N. Frega; Antonio Benedetti; Amalia Gastaldelli

doi:10.1111/j.1478-3231.2011.02462.x

Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis

Gianluca Svegliati-Baroni
, Stefania Saccomanno
, Sabina Saccomanno
, Chiara Rychlicki
, Laura Agostinelli
, Samuele De Minicis
, Cinzia Candelaresi
, Graziella Faraci
, Deborah Pacetti
, Marco Vivarelli
, Daniele Nicolini
, Paolo Garelli
, Alessandro Casini
, Melania Manco
, Geltrude Mingrone
, Andrea Risaliti
, Giuseppe N. Frega
, Antonio Benedetti
, Amalia Gastaldelli

Marche Polytechnic University
University of Florence
National Research Council of Italy

Risultato della ricerca: Contributo in rivista › Articolo

265 Citazioni (Scopus)

Abstract

High-fat dietary intake and low physical activity lead to insulin resistance, nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Recent studies have shown an effect of glucagon-like peptide-1 (GLP-1) on hepatic glucose metabolism, although GLP-1 receptors (GLP-1r) have not been found in human livers. The aim of this study was to investigate the presence of hepatic GLP-1r and the effect of exenatide, a GLP-1 analogue, on hepatic signalling.

Lingua originale	Inglese
pagine (da-a)	1285-1297
Numero di pagine	13
Rivista	Liver International
Volume	31
DOI	https://doi.org/10.1111/j.1478-3231.2011.02462.x
Stato di pubblicazione	Pubblicato - 2011

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Keywords

AMP-Activated Protein Kinases
Animals
Biopsy
Cyclic AMP-Dependent Protein Kinases
Dietary Fats
Disease Models, Animal
Fatty Acids
Fatty Liver
Gene Expression Regulation
Hep G2 Cells
Hepatocytes
Humans
Hypoglycemic Agents
Insulin Resistance
JNK Mitogen-Activated Protein Kinases
Liver
Male
Oxidation-Reduction
PPAR alpha
PPAR gamma
Peptides
Phosphorylation
Proto-Oncogene Proteins c-akt
Rats
Rats, Sprague-Dawley
Receptors, Glucagon
Signal Transduction
Time Factors
Venoms

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10.1111/j.1478-3231.2011.02462.x

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Svegliati-Baroni, G., Saccomanno, S., Saccomanno, S., Rychlicki, C., Agostinelli, L., De Minicis, S., Candelaresi, C., Faraci, G., Pacetti, D., Vivarelli, M., Nicolini, D., Garelli, P., Casini, A., Manco, M., Mingrone, G., Risaliti, A., Frega, G. N., Benedetti, A., & Gastaldelli, A. (2011). Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis. Liver International, 31, 1285-1297. https://doi.org/10.1111/j.1478-3231.2011.02462.x

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title = "Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis",

abstract = "High-fat dietary intake and low physical activity lead to insulin resistance, nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Recent studies have shown an effect of glucagon-like peptide-1 (GLP-1) on hepatic glucose metabolism, although GLP-1 receptors (GLP-1r) have not been found in human livers. The aim of this study was to investigate the presence of hepatic GLP-1r and the effect of exenatide, a GLP-1 analogue, on hepatic signalling.",

keywords = "AMP-Activated Protein Kinases, Animals, Biopsy, Cyclic AMP-Dependent Protein Kinases, Dietary Fats, Disease Models, Animal, Fatty Acids, Fatty Liver, Gene Expression Regulation, Hep G2 Cells, Hepatocytes, Humans, Hypoglycemic Agents, Insulin Resistance, JNK Mitogen-Activated Protein Kinases, Liver, Male, Oxidation-Reduction, PPAR alpha, PPAR gamma, Peptides, Phosphorylation, Proto-Oncogene Proteins c-akt, Rats, Rats, Sprague-Dawley, Receptors, Glucagon, Signal Transduction, Time Factors, Venoms, AMP-Activated Protein Kinases, Animals, Biopsy, Cyclic AMP-Dependent Protein Kinases, Dietary Fats, Disease Models, Animal, Fatty Acids, Fatty Liver, Gene Expression Regulation, Hep G2 Cells, Hepatocytes, Humans, Hypoglycemic Agents, Insulin Resistance, JNK Mitogen-Activated Protein Kinases, Liver, Male, Oxidation-Reduction, PPAR alpha, PPAR gamma, Peptides, Phosphorylation, Proto-Oncogene Proteins c-akt, Rats, Rats, Sprague-Dawley, Receptors, Glucagon, Signal Transduction, Time Factors, Venoms",

author = "Gianluca Svegliati-Baroni and Stefania Saccomanno and Sabina Saccomanno and Chiara Rychlicki and Laura Agostinelli and \{De Minicis\}, Samuele and Cinzia Candelaresi and Graziella Faraci and Deborah Pacetti and Marco Vivarelli and Daniele Nicolini and Paolo Garelli and Alessandro Casini and Melania Manco and Geltrude Mingrone and Andrea Risaliti and Frega, \{Giuseppe N.\} and Antonio Benedetti and Amalia Gastaldelli",

year = "2011",

doi = "10.1111/j.1478-3231.2011.02462.x",

language = "English",

volume = "31",

pages = "1285--1297",

journal = "Liver International",

issn = "1478-3223",

publisher = "Wiley-Blackwell",

}

Svegliati-Baroni, G, Saccomanno, S, Saccomanno, S, Rychlicki, C, Agostinelli, L, De Minicis, S, Candelaresi, C, Faraci, G, Pacetti, D, Vivarelli, M, Nicolini, D, Garelli, P, Casini, A, Manco, M, Mingrone, G, Risaliti, A, Frega, GN, Benedetti, A & Gastaldelli, A 2011, 'Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis', Liver International, vol. 31, pagg. 1285-1297. https://doi.org/10.1111/j.1478-3231.2011.02462.x

Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis. / Svegliati-Baroni, Gianluca; Saccomanno, Stefania; Saccomanno, Sabina et al.
In: Liver International, Vol. 31, 2011, pag. 1285-1297.

Risultato della ricerca: Contributo in rivista › Articolo

TY - JOUR

T1 - Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis

AU - Svegliati-Baroni, Gianluca

AU - Saccomanno, Stefania

AU - Saccomanno, Sabina

AU - Rychlicki, Chiara

AU - Agostinelli, Laura

AU - De Minicis, Samuele

AU - Candelaresi, Cinzia

AU - Faraci, Graziella

AU - Pacetti, Deborah

AU - Vivarelli, Marco

AU - Nicolini, Daniele

AU - Garelli, Paolo

AU - Casini, Alessandro

AU - Manco, Melania

AU - Mingrone, Geltrude

AU - Risaliti, Andrea

AU - Frega, Giuseppe N.

AU - Benedetti, Antonio

AU - Gastaldelli, Amalia

PY - 2011

Y1 - 2011

N2 - High-fat dietary intake and low physical activity lead to insulin resistance, nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Recent studies have shown an effect of glucagon-like peptide-1 (GLP-1) on hepatic glucose metabolism, although GLP-1 receptors (GLP-1r) have not been found in human livers. The aim of this study was to investigate the presence of hepatic GLP-1r and the effect of exenatide, a GLP-1 analogue, on hepatic signalling.

AB - High-fat dietary intake and low physical activity lead to insulin resistance, nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Recent studies have shown an effect of glucagon-like peptide-1 (GLP-1) on hepatic glucose metabolism, although GLP-1 receptors (GLP-1r) have not been found in human livers. The aim of this study was to investigate the presence of hepatic GLP-1r and the effect of exenatide, a GLP-1 analogue, on hepatic signalling.

KW - AMP-Activated Protein Kinases

KW - Animals

KW - Biopsy

KW - Cyclic AMP-Dependent Protein Kinases

KW - Dietary Fats

KW - Disease Models, Animal

KW - Fatty Acids

KW - Fatty Liver

KW - Gene Expression Regulation

KW - Hep G2 Cells

KW - Hepatocytes

KW - Humans

KW - Hypoglycemic Agents

KW - Insulin Resistance

KW - JNK Mitogen-Activated Protein Kinases

KW - Liver

KW - Male

KW - Oxidation-Reduction

KW - PPAR alpha

KW - PPAR gamma

KW - Peptides

KW - Phosphorylation

KW - Proto-Oncogene Proteins c-akt

KW - Rats

KW - Rats, Sprague-Dawley

KW - Receptors, Glucagon

KW - Signal Transduction

KW - Time Factors

KW - Venoms

KW - AMP-Activated Protein Kinases

KW - Animals

KW - Biopsy

KW - Cyclic AMP-Dependent Protein Kinases

KW - Dietary Fats

KW - Disease Models, Animal

KW - Fatty Acids

KW - Fatty Liver

KW - Gene Expression Regulation

KW - Hep G2 Cells

KW - Hepatocytes

KW - Humans

KW - Hypoglycemic Agents

KW - Insulin Resistance

KW - JNK Mitogen-Activated Protein Kinases

KW - Liver

KW - Male

KW - Oxidation-Reduction

KW - PPAR alpha

KW - PPAR gamma

KW - Peptides

KW - Phosphorylation

KW - Proto-Oncogene Proteins c-akt

KW - Rats

KW - Rats, Sprague-Dawley

KW - Receptors, Glucagon

KW - Signal Transduction

KW - Time Factors

KW - Venoms

UR - http://hdl.handle.net/10807/7236

U2 - 10.1111/j.1478-3231.2011.02462.x

DO - 10.1111/j.1478-3231.2011.02462.x

M3 - Article

SN - 1478-3223

VL - 31

SP - 1285

EP - 1297

JO - Liver International

JF - Liver International

ER -

Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis

Abstract

OSS delle Nazioni Unite

Keywords

Accesso al documento

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