@article{dc31fbb99b4a4d29b5a9e2df433f46ae,
title = "Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis",
abstract = "High-fat dietary intake and low physical activity lead to insulin resistance, nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Recent studies have shown an effect of glucagon-like peptide-1 (GLP-1) on hepatic glucose metabolism, although GLP-1 receptors (GLP-1r) have not been found in human livers. The aim of this study was to investigate the presence of hepatic GLP-1r and the effect of exenatide, a GLP-1 analogue, on hepatic signalling.",
keywords = "AMP-Activated Protein Kinases, Animals, Biopsy, Cyclic AMP-Dependent Protein Kinases, Dietary Fats, Disease Models, Animal, Fatty Acids, Fatty Liver, Gene Expression Regulation, Hep G2 Cells, Hepatocytes, Humans, Hypoglycemic Agents, Insulin Resistance, JNK Mitogen-Activated Protein Kinases, Liver, Male, Oxidation-Reduction, PPAR alpha, PPAR gamma, Peptides, Phosphorylation, Proto-Oncogene Proteins c-akt, Rats, Rats, Sprague-Dawley, Receptors, Glucagon, Signal Transduction, Time Factors, Venoms, AMP-Activated Protein Kinases, Animals, Biopsy, Cyclic AMP-Dependent Protein Kinases, Dietary Fats, Disease Models, Animal, Fatty Acids, Fatty Liver, Gene Expression Regulation, Hep G2 Cells, Hepatocytes, Humans, Hypoglycemic Agents, Insulin Resistance, JNK Mitogen-Activated Protein Kinases, Liver, Male, Oxidation-Reduction, PPAR alpha, PPAR gamma, Peptides, Phosphorylation, Proto-Oncogene Proteins c-akt, Rats, Rats, Sprague-Dawley, Receptors, Glucagon, Signal Transduction, Time Factors, Venoms",
author = "Geltrude Mingrone and Sabina Saccomanno and Melania Manco and Gianluca Svegliati-Baroni and Stefania Saccomanno and Chiara Rychlicki and Laura Agostinelli and {De Minicis}, Samuele and Cinzia Candelaresi and Graziella Faraci and Deborah Pacetti and Marco Vivarelli and Daniele Nicolini and Paolo Garelli and Alessandro Casini and Andrea Risaliti and Frega, {Giuseppe N.} and Antonio Benedetti and Amalia Gastaldelli",
year = "2011",
doi = "10.1111/j.1478-3231.2011.02462.x",
language = "English",
volume = "31",
pages = "1285--1297",
journal = "Liver International",
issn = "1478-3223",
publisher = "-MALDEN, USA: WILEY-BLACKWELL PUBLISHING -Copenhagen K Denmark: Blackwell Munksgaard",
}