Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis

Geltrude Mingrone, Sabina Saccomanno, Melania Manco, Gianluca Svegliati-Baroni, Stefania Saccomanno, Chiara Rychlicki, Laura Agostinelli, Samuele De Minicis, Cinzia Candelaresi, Graziella Faraci, Deborah Pacetti, Marco Vivarelli, Daniele Nicolini, Paolo Garelli, Alessandro Casini, Andrea Risaliti, Giuseppe N. Frega, Antonio Benedetti, Amalia Gastaldelli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

265 Citazioni (Scopus)

Abstract

High-fat dietary intake and low physical activity lead to insulin resistance, nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Recent studies have shown an effect of glucagon-like peptide-1 (GLP-1) on hepatic glucose metabolism, although GLP-1 receptors (GLP-1r) have not been found in human livers. The aim of this study was to investigate the presence of hepatic GLP-1r and the effect of exenatide, a GLP-1 analogue, on hepatic signalling.
Lingua originaleEnglish
pagine (da-a)1285-1297
Numero di pagine13
RivistaLiver International
Volume31
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • AMP-Activated Protein Kinases
  • Animals
  • Biopsy
  • Cyclic AMP-Dependent Protein Kinases
  • Dietary Fats
  • Disease Models, Animal
  • Fatty Acids
  • Fatty Liver
  • Gene Expression Regulation
  • Hep G2 Cells
  • Hepatocytes
  • Humans
  • Hypoglycemic Agents
  • Insulin Resistance
  • JNK Mitogen-Activated Protein Kinases
  • Liver
  • Male
  • Oxidation-Reduction
  • PPAR alpha
  • PPAR gamma
  • Peptides
  • Phosphorylation
  • Proto-Oncogene Proteins c-akt
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Glucagon
  • Signal Transduction
  • Time Factors
  • Venoms

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