Testing biologics and intracellular signaling inhibitors on pediatric atopic dermatitis: a stairway to modern therapeutic approaches

Andrea Chiricozzi, Diego Peroni, Giampiero Girolomoni

Risultato della ricerca: Contributo in rivistaArticolo in rivista

2 Citazioni (Scopus)

Abstract

Introduction: Atopic dermatitis (AD) is the most common cutaneous inflammatory disease in adults and children. In the last few years, the pathogenesis of AD has been profoundly revised, and this has led to the identification of novel druggable targets and the development of new agents targeting specific molecular pathways. Despite the high prevalence of AD in the pediatric population, the clinical development of new treatments, either topical or systemic, has been focused on the adult population in recent years; only a limited number of these new agents have been tested in pediatric cohorts. Areas covered: In this review, we describe the pathogenic model of pediatric AD which shows similarities and substantial differences when compared to adult AD. The identification of therapeutic targets is highlighted, and novel targeted therapies, both topical and systemic, are discussed. Expert opinion: The current therapeutic armamentarium for pediatric AD is very limited, and this represents a critical unmet need. The enhancement of clinical research on pediatric patients is necessary to facilitate an increase in the number of new targeted therapeutic options being available on the market.
Lingua originaleEnglish
pagine (da-a)699-707
Numero di pagine9
RivistaExpert Opinion on Investigational Drugs
Volume27
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • Administration, Cutaneous
  • Adult
  • Biological Products
  • Child
  • Dermatitis, Atopic
  • Dermatologic Agents
  • Drug Design
  • Humans
  • JAK inhibitor
  • Molecular Targeted Therapy
  • PDE4 inhibitor
  • Pediatric atopic dermatitis
  • Pharmacology
  • Pharmacology (medical)
  • Signal Transduction
  • biologic
  • targeted drugs

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