Testicular FasL is expressed by sperm cells

Alessio D'Alessio, A Riccioli, P Lauretti, F Padula, B Muciaccia, P De Cesaris, A Filippini, S Nagata, E. Ziparo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

117 Citazioni (Scopus)

Abstract

The testis is the main source of Fas ligand (FasL) mRNA in rodents; it is generally believed that this molecule, expressed on bordering somatic Sertoli cells, bestows an immune-privileged status in the testis by eliminating infiltrating inflammatory Fas-bearing leukocytes. Our results demonstrate that the attribution of testicular expression of FasL to Sertoli cells is erroneous and that FasL transcription instead occurs in meiotic and postmeiotic germ cells, whereas the protein is only displayed on mature spermatozoa. These findings point to a significant role of the Fas system in the biology of mammalian reproduction.
Lingua originaleEnglish
pagine (da-a)3316-3321
Numero di pagine6
RivistaProceedings of the National Academy of Sciences of the United States of America
Volume98
DOI
Stato di pubblicazionePubblicato - 2001

Keywords

  • Animals
  • Cells, Cultured
  • Fas Ligand Protein
  • Gene Expression
  • Male
  • Membrane Glycoproteins
  • Mice
  • Rats
  • Rats, Wistar
  • Sertoli Cells
  • Spermatozoa
  • Testis

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