TY - JOUR
T1 - Tea consumption and gastric cancer: a pooled analysis from the Stomach cancer Pooling (StoP) Project consortium
AU - Martimianaki, Georgia
AU - Alicandro, Gianfranco
AU - Pelucchi, Claudio
AU - Bonzi, Rossella
AU - Rota, Matteo
AU - Hu, Jinfu
AU - Johnson, Kenneth C.
AU - Rabkin, Charles S.
AU - Liao, Linda M.
AU - Sinha, Rashmi
AU - Zhang, Zuo-Feng
AU - Dalmartello, Michela
AU - Lunet, Nuno
AU - Lunet, Nuno Miguel De Sousa
AU - Morais, Samantha
AU - Palli, Domenico
AU - Ferraroni, Monica
AU - Yu, Guo-Pei
AU - Tsugane, Shoichiro
AU - Hidaka, Akihisa
AU - Curado, Maria Paula
AU - Dias-Neto, Emmanuel
AU - Zaridze, David
AU - Maximovitch, Dmitry
AU - Vioque, Jesus
AU - Garcia De La Hera, Manoli
AU - López-Carrillo, Lizbeth
AU - Hernández-Ramírez, Raúl Ulises
AU - Hamada, Gerson Shigueaki
AU - Ward, Mary H.
AU - Mu, Lina
AU - Malekzadeh, Reza
AU - Pourfarzi, Farhad
AU - Trichopoulou, Antonia
AU - Karakatsani, Anna
AU - Kurtz, Robert C.
AU - Lagiou, Areti
AU - Lagiou, Pagona
AU - Boccia, Stefania
AU - Boffetta, Paolo
AU - Camargo, M. Constanza
AU - Negri, Eva
AU - La Vecchia, Carlo
PY - 2022
Y1 - 2022
N2 - Background Evidence from epidemiological studies on the role of tea drinking in gastric cancer risk remains inconsistent. We aimed to investigate and quantify the relationship between tea consumption and gastric cancer in the Stomach cancer Pooling (StoP) Project consortium. Methods A total of 9438 cases and 20,451 controls from 22 studies worldwide were included. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) of gastric cancer for regular versus non-regular tea drinkers were estimated by one and two-stage modelling analyses, including terms for sex, age and the main recognised risk factors for gastric cancer. Results Compared to non-regular drinkers, the estimated adjusted pooled OR for regular tea drinkers was 0.91 (95% CI: 0.85-0.97). When the amount of tea consumed was considered, the OR for consumption of 1-2 cups/day was 1.01 (95% CI: 0.94-1.09) and for >3 cups/day was 0.91 (95% CI: 0.80-1.03). Stronger inverse associations emerged among regular drinkers in China and Japan (OR: 0.67, 95% CI: 0.49-0.91) where green tea is consumed, in subjects with H. pylori infection (OR: 0.68, 95% CI: 0.58-0.80), and for gastric cardia cancer (OR: 0.64, 95% CI: 0.49-0.84). Conclusion Our results indicate a weak inverse association between tea consumption and gastric cancer.
AB - Background Evidence from epidemiological studies on the role of tea drinking in gastric cancer risk remains inconsistent. We aimed to investigate and quantify the relationship between tea consumption and gastric cancer in the Stomach cancer Pooling (StoP) Project consortium. Methods A total of 9438 cases and 20,451 controls from 22 studies worldwide were included. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) of gastric cancer for regular versus non-regular tea drinkers were estimated by one and two-stage modelling analyses, including terms for sex, age and the main recognised risk factors for gastric cancer. Results Compared to non-regular drinkers, the estimated adjusted pooled OR for regular tea drinkers was 0.91 (95% CI: 0.85-0.97). When the amount of tea consumed was considered, the OR for consumption of 1-2 cups/day was 1.01 (95% CI: 0.94-1.09) and for >3 cups/day was 0.91 (95% CI: 0.80-1.03). Stronger inverse associations emerged among regular drinkers in China and Japan (OR: 0.67, 95% CI: 0.49-0.91) where green tea is consumed, in subjects with H. pylori infection (OR: 0.68, 95% CI: 0.58-0.80), and for gastric cardia cancer (OR: 0.64, 95% CI: 0.49-0.84). Conclusion Our results indicate a weak inverse association between tea consumption and gastric cancer.
KW - gastric cancer risk
KW - tea consumption
KW - gastric cancer risk
KW - tea consumption
UR - http://hdl.handle.net/10807/225909
U2 - 10.1038/s41416-022-01856-w
DO - 10.1038/s41416-022-01856-w
M3 - Article
SN - 0007-0920
VL - 127
SP - 726
EP - 734
JO - British Journal of Cancer
JF - British Journal of Cancer
ER -
