Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis

A. E. Elia; Antonio Emanuele Elia; S. Lalli; M. R. Monsurrò; A. Sagnelli; A. C. Taiello; B. Reggiori; V. La Bella; G. Tedeschi; Alberto Albanese

doi:10.1111/ene.12664

Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis

A. E. Elia
, Antonio Emanuele Elia
, S. Lalli
, M. R. Monsurrò
, A. Sagnelli
, A. C. Taiello
, B. Reggiori
, V. La Bella
, G. Tedeschi
, Alberto Albanese

IRCCS Fondazione Istituto Neurologico Carlo Besta - Milano
University of Campania Luigi Vanvitelli
University of Palermo

Risultato della ricerca: Contributo in rivista › Articolo › peer review

90 Citazioni (Scopus)

Abstract

Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid that is produced in the liver and used for treatment of chronic cholestatic liver diseases. Experimental studies suggest that TUDCA may have cytoprotective and anti-apoptotic action, with potential neuroprotective activity. A proof of principle approach was adopted to provide preliminary data regarding the efficacy and tolerability of TUDCA in a series of patients with amyotrophic lateral sclerosis (ALS).

Lingua originale	Inglese
pagine (da-a)	N/A-N/A
Numero di pagine	11
Rivista	European Journal of Neurology
DOI	https://doi.org/10.1111/ene.12664
Stato di pubblicazione	Pubblicato - 2015

Keywords

amyotrophic lateral sclerosis
cholic acids
tauroursodeoxycholic acid

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10.1111/ene.12664

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title = "Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis",

abstract = "Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid that is produced in the liver and used for treatment of chronic cholestatic liver diseases. Experimental studies suggest that TUDCA may have cytoprotective and anti-apoptotic action, with potential neuroprotective activity. A proof of principle approach was adopted to provide preliminary data regarding the efficacy and tolerability of TUDCA in a series of patients with amyotrophic lateral sclerosis (ALS).",

keywords = "amyotrophic lateral sclerosis, cholic acids, tauroursodeoxycholic acid, amyotrophic lateral sclerosis, cholic acids, tauroursodeoxycholic acid",

author = "Elia, \{A. E.\} and Elia, \{Antonio Emanuele\} and S. Lalli and Monsurr{\`o}, \{M. R.\} and A. Sagnelli and Taiello, \{A. C.\} and B. Reggiori and \{La Bella\}, V. and G. Tedeschi and Alberto Albanese",

year = "2015",

doi = "10.1111/ene.12664",

language = "English",

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journal = "European Journal of Neurology",

issn = "1468-1331",

publisher = "John Wiley and Sons Inc.",

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TY - JOUR

T1 - Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis

AU - Elia, A. E.

AU - Elia, Antonio Emanuele

AU - Lalli, S.

AU - Monsurrò, M. R.

AU - Sagnelli, A.

AU - Taiello, A. C.

AU - Reggiori, B.

AU - La Bella, V.

AU - Tedeschi, G.

AU - Albanese, Alberto

PY - 2015

Y1 - 2015

N2 - Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid that is produced in the liver and used for treatment of chronic cholestatic liver diseases. Experimental studies suggest that TUDCA may have cytoprotective and anti-apoptotic action, with potential neuroprotective activity. A proof of principle approach was adopted to provide preliminary data regarding the efficacy and tolerability of TUDCA in a series of patients with amyotrophic lateral sclerosis (ALS).

AB - Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid that is produced in the liver and used for treatment of chronic cholestatic liver diseases. Experimental studies suggest that TUDCA may have cytoprotective and anti-apoptotic action, with potential neuroprotective activity. A proof of principle approach was adopted to provide preliminary data regarding the efficacy and tolerability of TUDCA in a series of patients with amyotrophic lateral sclerosis (ALS).

KW - amyotrophic lateral sclerosis

KW - cholic acids

KW - tauroursodeoxycholic acid

KW - amyotrophic lateral sclerosis

KW - cholic acids

KW - tauroursodeoxycholic acid

UR - http://hdl.handle.net/10807/66605

U2 - 10.1111/ene.12664

DO - 10.1111/ene.12664

M3 - Article

SN - 1468-1331

SP - N/A-N/A

JO - European Journal of Neurology

JF - European Journal of Neurology

ER -

Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis

Abstract

Keywords

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