Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis

A. E. Elia; Antonio Emanuele Elia; S. Lalli; M. R. Monsurrò; A. Sagnelli; A. C. Taiello; B. Reggiori; V. La Bella; G. Tedeschi; Alberto Albanese

doi:10.1111/ene.12664

Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis

A. E. Elia, Antonio Emanuele Elia, S. Lalli, M. R. Monsurrò, A. Sagnelli, A. C. Taiello, B. Reggiori, V. La Bella, G. Tedeschi, Alberto Albanese

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

90 Citazioni (Scopus)

Abstract

Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid that is produced in the liver and used for treatment of chronic cholestatic liver diseases. Experimental studies suggest that TUDCA may have cytoprotective and anti-apoptotic action, with potential neuroprotective activity. A proof of principle approach was adopted to provide preliminary data regarding the efficacy and tolerability of TUDCA in a series of patients with amyotrophic lateral sclerosis (ALS).

Lingua originale	English
pagine (da-a)	N/A-N/A
Numero di pagine	11
Rivista	European Journal of Neurology
DOI	https://doi.org/10.1111/ene.12664
Stato di pubblicazione	Pubblicato - 2015

Keywords

amyotrophic lateral sclerosis
cholic acids
tauroursodeoxycholic acid

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10.1111/ene.12664

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abstract = "Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid that is produced in the liver and used for treatment of chronic cholestatic liver diseases. Experimental studies suggest that TUDCA may have cytoprotective and anti-apoptotic action, with potential neuroprotective activity. A proof of principle approach was adopted to provide preliminary data regarding the efficacy and tolerability of TUDCA in a series of patients with amyotrophic lateral sclerosis (ALS).",

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TY - JOUR

T1 - Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis

AU - Elia, A. E.

AU - Elia, Antonio Emanuele

AU - Lalli, S.

AU - Monsurrò, M. R.

AU - Sagnelli, A.

AU - Taiello, A. C.

AU - Reggiori, B.

AU - La Bella, V.

AU - Tedeschi, G.

AU - Albanese, Alberto

PY - 2015

Y1 - 2015

N2 - Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid that is produced in the liver and used for treatment of chronic cholestatic liver diseases. Experimental studies suggest that TUDCA may have cytoprotective and anti-apoptotic action, with potential neuroprotective activity. A proof of principle approach was adopted to provide preliminary data regarding the efficacy and tolerability of TUDCA in a series of patients with amyotrophic lateral sclerosis (ALS).

AB - Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid that is produced in the liver and used for treatment of chronic cholestatic liver diseases. Experimental studies suggest that TUDCA may have cytoprotective and anti-apoptotic action, with potential neuroprotective activity. A proof of principle approach was adopted to provide preliminary data regarding the efficacy and tolerability of TUDCA in a series of patients with amyotrophic lateral sclerosis (ALS).

KW - amyotrophic lateral sclerosis

KW - cholic acids

KW - tauroursodeoxycholic acid

KW - amyotrophic lateral sclerosis

KW - cholic acids

KW - tauroursodeoxycholic acid

UR - http://hdl.handle.net/10807/66605

U2 - 10.1111/ene.12664

DO - 10.1111/ene.12664

M3 - Article

SN - 1468-1331

SP - N/A-N/A

JO - European Journal of Neurology

JF - European Journal of Neurology

ER -

Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis

Abstract

Keywords

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