Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis

Alberto Albanese, Antonio Emanuele Elia, A. E. Elia, S. Lalli, M. R. Monsurrò, A. Sagnelli, A. C. Taiello, B. Reggiori, V. La Bella, G. Tedeschi

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

85 Citazioni (Scopus)

Abstract

Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid that is produced in the liver and used for treatment of chronic cholestatic liver diseases. Experimental studies suggest that TUDCA may have cytoprotective and anti-apoptotic action, with potential neuroprotective activity. A proof of principle approach was adopted to provide preliminary data regarding the efficacy and tolerability of TUDCA in a series of patients with amyotrophic lateral sclerosis (ALS).
Lingua originaleEnglish
pagine (da-a)N/A-N/A
Numero di pagine11
RivistaEUROPEAN JOURNAL OF NEUROLOGY
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • amyotrophic lateral sclerosis
  • cholic acids
  • tauroursodeoxycholic acid

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