TY - JOUR
T1 - Taurine Administration Counteracts Aging-Associated Impingement of Skeletal Muscle Regeneration by Reducing Inflammation and Oxidative Stress
AU - Barbiera, Alessandra
AU - Sorrentino, Silvia
AU - Fard, Damon
AU - Lepore, Elisa
AU - Sica, Gigliola
AU - Dobrowolny, Gabriella
AU - Tamagnone, Luca
AU - Scicchitano, Bianca Maria
PY - 2022
Y1 - 2022
N2 - Abstract: Sarcopenia, which occurs during aging, is characterized by the gradual loss of skeletal
muscle mass and function, resulting in a functional decline in physical abilities. Several factors
contribute to the onset of sarcopenia, including reduced regenerative capacity, chronic low-grade
inflammation, mitochondrial dysfunction, and increased oxidative stress, leading to the activation of
catabolic pathways. Physical activity and adequate protein intake are considered effective strategies
able to reduce the incidence and severity of sarcopenia by exerting beneficial effects in improving
the muscular anabolic response during aging. Taurine is a non-essential amino acid that is highly
expressed in mammalian tissues and, particularly, in skeletal muscle where it is involved in the
regulation of biological processes and where it acts as an antioxidant and anti-inflammatory factor.
Here, we evaluated whether taurine administration in old mice counteracts the physiopathological
effects of aging in skeletal muscle. We showed that, in injured muscle, taurine enhances the regenerative process by downregulating the inflammatory response and preserving muscle fiber integrity.
Moreover, taurine attenuates ROS production in aged muscles by maintaining a proper cellular
redox balance, acting as an antioxidant molecule. Although further studies are needed to better
elucidate the molecular mechanisms responsible for the beneficial effect of taurine on skeletal muscle
homeostasis, these data demonstrate that taurine administration ameliorates the microenvironment
allowing an efficient regenerative process and attenuation of the catabolic pathways related to the
onset of sarcopenia.
AB - Abstract: Sarcopenia, which occurs during aging, is characterized by the gradual loss of skeletal
muscle mass and function, resulting in a functional decline in physical abilities. Several factors
contribute to the onset of sarcopenia, including reduced regenerative capacity, chronic low-grade
inflammation, mitochondrial dysfunction, and increased oxidative stress, leading to the activation of
catabolic pathways. Physical activity and adequate protein intake are considered effective strategies
able to reduce the incidence and severity of sarcopenia by exerting beneficial effects in improving
the muscular anabolic response during aging. Taurine is a non-essential amino acid that is highly
expressed in mammalian tissues and, particularly, in skeletal muscle where it is involved in the
regulation of biological processes and where it acts as an antioxidant and anti-inflammatory factor.
Here, we evaluated whether taurine administration in old mice counteracts the physiopathological
effects of aging in skeletal muscle. We showed that, in injured muscle, taurine enhances the regenerative process by downregulating the inflammatory response and preserving muscle fiber integrity.
Moreover, taurine attenuates ROS production in aged muscles by maintaining a proper cellular
redox balance, acting as an antioxidant molecule. Although further studies are needed to better
elucidate the molecular mechanisms responsible for the beneficial effect of taurine on skeletal muscle
homeostasis, these data demonstrate that taurine administration ameliorates the microenvironment
allowing an efficient regenerative process and attenuation of the catabolic pathways related to the
onset of sarcopenia.
KW - Neurohypohyseal hormones
KW - Skeletal muscle
KW - Neurohypohyseal hormones
KW - Skeletal muscle
UR - http://hdl.handle.net/10807/207885
U2 - 10.3390/antiox11051016
DO - 10.3390/antiox11051016
M3 - Article
SN - 2076-3921
VL - 11
SP - 1016-N/A
JO - Antioxidants
JF - Antioxidants
ER -