Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

Filippo Crea, Dario Pitocco, Gaetano Antonio Lanza, Domenico D'Amario, Angelo Villano, Massimo Volpe, Francesco Paneni, Sarah Costantino, Lorenzo Castello, Rodolfo Battista, Giuliana Capretti, Sergio Chiandotto, Alessandra Rustighi, Giannino Del Sal, Thomas F. Lüscher, Francesco Cosentino

Risultato della ricerca: Contributo in rivistaArticolo in rivista

52 Citazioni (Scopus)

Abstract

Diabetes is a major driver of cardiovascular disease, but the underlying mechanisms remain elusive. Prolyl-isomerase Pin1 recognizes specific peptide bonds and modulates function of proteins altering cellular homoeostasis. The present study investigates Pin1 role in diabetes-induced vascular disease.
Lingua originaleEnglish
pagine (da-a)817-828
Numero di pagine12
RivistaEuropean Heart Journal
Volume36
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • Diabetes mellitus
  • Endothelial function
  • Inflammation
  • Oxidative stress

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