Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

F Paneni; S Costantino; L Castello; R Battista; G Capretti; S Chiandotto; Domenico D'Amario; G Scavone; Angelo Villano; A Rustighi; Filippo Crea; Dario Pitocco; Gaetano Antonio Lanza; Massimo Volpe; G Del Sal; Tf Lüscher; F. Cosentino

doi:10.1093/eurheartj/ehu179

Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

F Paneni, S Costantino, L Castello, R Battista, G Capretti, S Chiandotto, Domenico D'Amario, G Scavone, Angelo Villano, A Rustighi, Filippo Crea, Dario Pitocco, Gaetano Antonio Lanza, Massimo Volpe, G Del Sal, Tf Lüscher, F. Cosentino^*

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

53 Citazioni (Scopus)

Abstract

Diabetes is a major driver of cardiovascular disease, but the underlying mechanisms remain elusive. Prolyl-isomerase Pin1 recognizes specific peptide bonds and modulates function of proteins altering cellular homoeostasis. The present study investigates Pin1 role in diabetes-induced vascular disease.

Lingua originale	Inglese
pagine (da-a)	817-828
Numero di pagine	12
Rivista	European Heart Journal
Volume	36
Numero di pubblicazione	13
DOI	https://doi.org/10.1093/eurheartj/ehu179
Stato di pubblicazione	Pubblicato - 2015

All Science Journal Classification (ASJC) codes

Cardiologia e Medicina Cardiovascolare

Keywords

Diabetes mellitus
Endothelial function
Inflammation
Oxidative stress

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10.1093/eurheartj/ehu179

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Paneni, F., Costantino, S., Castello, L., Battista, R., Capretti, G., Chiandotto, S., D'Amario, D., Scavone, G., Villano, A., Rustighi, A., Crea, F., Pitocco, D., Lanza, G. A., Volpe, M., Del Sal, G., Lüscher, T., & Cosentino, F. (2015). Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes. European Heart Journal, 36(13), 817-828. https://doi.org/10.1093/eurheartj/ehu179

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title = "Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes",

abstract = "Diabetes is a major driver of cardiovascular disease, but the underlying mechanisms remain elusive. Prolyl-isomerase Pin1 recognizes specific peptide bonds and modulates function of proteins altering cellular homoeostasis. The present study investigates Pin1 role in diabetes-induced vascular disease.",

keywords = "Diabetes mellitus, Endothelial function, Inflammation, Oxidative stress, Diabetes mellitus, Endothelial function, Inflammation, Oxidative stress",

author = "F Paneni and S Costantino and L Castello and R Battista and G Capretti and S Chiandotto and Domenico D'Amario and G Scavone and Angelo Villano and A Rustighi and Filippo Crea and Dario Pitocco and Lanza, {Gaetano Antonio} and Massimo Volpe and {Del Sal}, G and Tf L{\"u}scher and F. Cosentino",

year = "2015",

doi = "10.1093/eurheartj/ehu179",

language = "English",

volume = "36",

pages = "817--828",

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Paneni, F, Costantino, S, Castello, L, Battista, R, Capretti, G, Chiandotto, S, D'Amario, D, Scavone, G, Villano, A, Rustighi, A, Crea, F, Pitocco, D , Lanza, GA, Volpe, M, Del Sal, G, Lüscher, T & Cosentino, F 2015, 'Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes', European Heart Journal, vol. 36, n. 13, pagg. 817-828. https://doi.org/10.1093/eurheartj/ehu179

TY - JOUR

T1 - Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

AU - Paneni, F

AU - Costantino, S

AU - Castello, L

AU - Battista, R

AU - Capretti, G

AU - Chiandotto, S

AU - D'Amario, Domenico

AU - Scavone, G

AU - Villano, Angelo

AU - Rustighi, A

AU - Crea, Filippo

AU - Pitocco, Dario

AU - Lanza, Gaetano Antonio

AU - Volpe, Massimo

AU - Del Sal, G

AU - Lüscher, Tf

AU - Cosentino, F.

PY - 2015

Y1 - 2015

N2 - Diabetes is a major driver of cardiovascular disease, but the underlying mechanisms remain elusive. Prolyl-isomerase Pin1 recognizes specific peptide bonds and modulates function of proteins altering cellular homoeostasis. The present study investigates Pin1 role in diabetes-induced vascular disease.

AB - Diabetes is a major driver of cardiovascular disease, but the underlying mechanisms remain elusive. Prolyl-isomerase Pin1 recognizes specific peptide bonds and modulates function of proteins altering cellular homoeostasis. The present study investigates Pin1 role in diabetes-induced vascular disease.

KW - Diabetes mellitus

KW - Endothelial function

KW - Inflammation

KW - Oxidative stress

KW - Diabetes mellitus

KW - Endothelial function

KW - Inflammation

KW - Oxidative stress

UR - https://publicatt.unicatt.it/handle/10807/69144

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U2 - 10.1093/eurheartj/ehu179

DO - 10.1093/eurheartj/ehu179

M3 - Article

SN - 0195-668X

VL - 36

SP - 817

EP - 828

JO - European Heart Journal

JF - European Heart Journal

IS - 13

ER -

Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

Abstract

All Science Journal Classification (ASJC) codes

Keywords

OSS delle Nazioni Unite

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