Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

Francesco Paneni; Sarah Costantino; Lorenzo Castello; Rodolfo Battista; Giuliana Capretti; Sergio Chiandotto; Domenico D'Amario; Giuseppe Scavone; Angelo Villano; Alessandra Rustighi; Filippo Crea; Dario Pitocco; Gaetano Antonio Lanza; Massimo Volpe; Giannino De Sal; Thomas Luscher; Francesco Cosentino

doi:10.1093/eurheartj/ehu179

Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

Francesco Paneni
, Sarah Costantino
, Lorenzo Castello
, Rodolfo Battista
, Giuliana Capretti
, Sergio Chiandotto
, Domenico D'Amario
, Giuseppe Scavone
, Angelo Villano
, Alessandra Rustighi
, Filippo Crea
, Dario Pitocco
, Gaetano Antonio Lanza
, Massimo Volpe
, Giannino De Sal
, Thomas Luscher
, Francesco Cosentino^*

^*Autore corrispondente per questo lavoro

University of Zurich
Karolinska Institutet
IRCCS Istituto Neurologico Mediterraneo Neuromed - Pozzilli (IS)
University of Rome La Sapienza
University of Trieste

Risultato della ricerca: Contributo in rivista › Articolo

53 Citazioni (Scopus)

Abstract

Diabetes is a major driver of cardiovascular disease, but the underlying mechanisms remain elusive. Prolyl-isomerase Pin1 recognizes specific peptide bonds and modulates function of proteins altering cellular homoeostasis. The present study investigates Pin1 role in diabetes-induced vascular disease.

Lingua originale	Inglese
pagine (da-a)	N/A-N/A
Rivista	European Heart Journal
Numero di pubblicazione	Maggio
DOI	https://doi.org/10.1093/eurheartj/ehu179
Stato di pubblicazione	Pubblicato - 2014

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

SDG 3 Salute e benessere

All Science Journal Classification (ASJC) codes

Cardiologia e Medicina Cardiovascolare

Keywords

Diabetes mellitus
Endothelial function
Inflammation
Oxidative stress

Accesso al documento

10.1093/eurheartj/ehu179

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Paneni, F., Costantino, S., Castello, L., Battista, R., Capretti, G., Chiandotto, S., D'Amario, D., Scavone, G., Villano, A., Rustighi, A., Crea, F., Pitocco, D., Lanza, G. A., Volpe, M., De Sal, G., Luscher, T., & Cosentino, F. (2014). Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes. European Heart Journal, (Maggio), N/A-N/A. https://doi.org/10.1093/eurheartj/ehu179

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title = "Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes",

abstract = "Diabetes is a major driver of cardiovascular disease, but the underlying mechanisms remain elusive. Prolyl-isomerase Pin1 recognizes specific peptide bonds and modulates function of proteins altering cellular homoeostasis. The present study investigates Pin1 role in diabetes-induced vascular disease.",

keywords = "Diabetes mellitus, Endothelial function, Inflammation, Oxidative stress, Diabetes mellitus, Endothelial function, Inflammation, Oxidative stress",

author = "Francesco Paneni and Sarah Costantino and Lorenzo Castello and Rodolfo Battista and Giuliana Capretti and Sergio Chiandotto and Domenico D'Amario and Giuseppe Scavone and Angelo Villano and Alessandra Rustighi and Filippo Crea and Dario Pitocco and Lanza, \{Gaetano Antonio\} and Massimo Volpe and \{De Sal\}, Giannino and Thomas Luscher and Francesco Cosentino",

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doi = "10.1093/eurheartj/ehu179",

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Paneni, F, Costantino, S, Castello, L, Battista, R, Capretti, G, Chiandotto, S, D'Amario, D, Scavone, G, Villano, A, Rustighi, A, Crea, F, Pitocco, D , Lanza, GA, Volpe, M, De Sal, G, Luscher, T & Cosentino, F 2014, 'Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes', European Heart Journal, n. Maggio, pagg. N/A-N/A. https://doi.org/10.1093/eurheartj/ehu179

TY - JOUR

T1 - Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

AU - Paneni, Francesco

AU - Costantino, Sarah

AU - Castello, Lorenzo

AU - Battista, Rodolfo

AU - Capretti, Giuliana

AU - Chiandotto, Sergio

AU - D'Amario, Domenico

AU - Scavone, Giuseppe

AU - Villano, Angelo

AU - Rustighi, Alessandra

AU - Crea, Filippo

AU - Pitocco, Dario

AU - Lanza, Gaetano Antonio

AU - Volpe, Massimo

AU - De Sal, Giannino

AU - Luscher, Thomas

AU - Cosentino, Francesco

PY - 2014

Y1 - 2014

N2 - Diabetes is a major driver of cardiovascular disease, but the underlying mechanisms remain elusive. Prolyl-isomerase Pin1 recognizes specific peptide bonds and modulates function of proteins altering cellular homoeostasis. The present study investigates Pin1 role in diabetes-induced vascular disease.

AB - Diabetes is a major driver of cardiovascular disease, but the underlying mechanisms remain elusive. Prolyl-isomerase Pin1 recognizes specific peptide bonds and modulates function of proteins altering cellular homoeostasis. The present study investigates Pin1 role in diabetes-induced vascular disease.

KW - Diabetes mellitus

KW - Endothelial function

KW - Inflammation

KW - Oxidative stress

KW - Diabetes mellitus

KW - Endothelial function

KW - Inflammation

KW - Oxidative stress

UR - https://publicatt.unicatt.it/handle/10807/60914

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U2 - 10.1093/eurheartj/ehu179

DO - 10.1093/eurheartj/ehu179

M3 - Article

SN - 0195-668X

SP - N/A-N/A

JO - European Heart Journal

JF - European Heart Journal

IS - Maggio

ER -

Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

Abstract

OSS delle Nazioni Unite

All Science Journal Classification (ASJC) codes

Keywords

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