Targeting inflammation: Impact on atherothrombosis

Luigi Marzio Biasucci, Maria Giulia Marini, Chiara Sonnino

Risultato della ricerca: Contributo in rivistaArticolo in rivista

15 Citazioni (Scopus)

Abstract

Atherothrombosis is a worldwide epidemic accounting for an unacceptable toll of deaths and disabilities. Its pathophysiology is complex and hardly referable to a specific mechanism; however, in the last 20 years, a growing amount of evidence has demonstrated that inflammatory processes play a major role from the very beginning to the ultimate complication of atherothrombosis. These evidences are addressing a growing interest toward anti-inflammatory agents as preventive or curative treatments of atherothrombosis. At present, accumulated data are not conclusive, but strong evidence exists in favor of an anti-inflammatory positive effect for several drugs as statins or renin-angiotensin inhibitors. More conclusive data are expected from ongoing trials directly exploring the role of specific cytokines antagonists. © 2013 Springer Science+Business Media New York.
Lingua originaleEnglish
pagine (da-a)9-18
Numero di pagine10
RivistaJournal of Cardiovascular Translational Research
Volume7
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • 3003
  • Acute coronary syndrome
  • Animals
  • Anti-Inflammatory Agents
  • Anti-inflammatory drugs
  • Atherosclerosis
  • Atherothrombosis
  • Cardiology and Cardiovascular Medicine
  • Cytokines
  • Fibrinolytic Agents
  • Genetics
  • Genetics (clinical)
  • Humans
  • Inflammation
  • Inflammation Mediators
  • Molecular Medicine
  • Molecular Targeted Therapy
  • Signal Transduction
  • Thrombosis
  • Treatment Outcome

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