Targeting IL-4 for the Treatment of Atopic Dermatitis

Andrea Chiricozzi, Ketty Peris, Martina Maurelli, Giampiero Girolomoni

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Atopic dermatitis (AD) is an immune-mediated inflammatory skin disease characterized by a predominant type 2 immune response. Type 2 immunity is driven by multiple cytokines, including interleukin (IL)-4 and IL-13 that are considered central to AD pathogenesis and key therapeutic targets. The dual inhibition of these two cytokines or the selective inhibition of IL-13 proved elevated efficacy in treating AD, whereas the selective inhibition of IL-4 has been poorly investigated as IL-4 inhibiting agents did not show any advance in clinical development programs. This review describes the pathogenic role of IL-4 in AD and briefly resumes the main features of compounds selectively blocking IL-4.
Lingua originaleEnglish
pagine (da-a)151-156-156
RivistaImmunoTargets and Therapy
Volume9
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • IL-4
  • IL-4 inhibitor
  • atopic dermatitis
  • dupilumab
  • pascolizumab
  • pitrakinra

Fingerprint

Entra nei temi di ricerca di 'Targeting IL-4 for the Treatment of Atopic Dermatitis'. Insieme formano una fingerprint unica.

Cita questo