Targeted Therapies in Combination with Radiotherapy in Oesophageal and Gastroesophageal Carcinoma

Vincenzo Valentini, Francesco Cellini, F. Cellini

Risultato della ricerca: Contributo in rivistaArticolo in rivista

10 Citazioni (Scopus)

Abstract

Oesophageal cancer is the sixth cause of cancer-related death worldwide. Nowadays radiochemotherapy (RTCT) plays a central role in the treatment settings of such disease. Evaluation of molecular targeted therapies is an attractive opportunity for the management of oesophageal, GEJ and gastric cancers to improve outcomes as happened for other primary tumours. Clinical trials focused on the potential of many molecular targeted agents included in CT schedules, but also on the possibility, efficacy and tolerance of their use combined with RT. This review will focus on the over 15 more promising agents studied in combination with RT for esophagogastric tumour, describing the mechanism and target of action, evidences and potential future role on over 50 trials evaluated. Mechanisms of action, studies and evidences about Human Epidermal Growth Factor type 2 Targeting Agents (one of the more promising), Epidermal Growth Factor's Receptor Inhibitors (nowadays showing a lower potential than expected), Vascular Endothelial Growth Factor Inhibitors, Mesenchymal Epithelial Transition Factor, Hepatocyte Growth Factor and other targeting agents are reviewed.
Lingua originaleEnglish
pagine (da-a)990-1004
Numero di pagine15
RivistaCURRENT MEDICINAL CHEMISTRY
Volume21
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • radiotherapy

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