Tamoxifen related Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A case report and literature review of this possible association

Giovanni Scambia, Gian Franco Zannoni, Angela Santoro, Diego Segala, Stefano Gobbo, Anna Pesci, Guido Martignoni

Risultato della ricerca: Contributo in rivistaArticolo in rivista

1 Citazioni (Scopus)

Abstract

It is well known that a large number of patients treated with Tamoxifen develops endometrial pathologies ranging from benign endometrial polyps and hyperplasia to adenocarcinomas, carcinosarcomas and adenosarcomas. UTROSCT (Uterine Tumor Resembling Ovarian Sex Cord Tumor) is defined as a mesenchymal tumors of the uterine corpus that morphologically resembles ovarian sex cord tumors, without recognizable endometrial stroma. To date only 4 cases have been reported in patients treated with tamoxifen. In this article, we describe an additional case occurring in a 62-years-old patient undergoing 3 years of Tamoxifen therapy for bilateral breast carcinoma. The present work represents a further evidence of the possible association between Tamoxifen therapy and UTROSCT. A comprehensive literature review on this topic is also provided.
Lingua originaleEnglish
pagine (da-a)1089-1092
Numero di pagine7
RivistaPathology Research and Practice
Volume215
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • 2734
  • Breast cancer
  • Cell Biology
  • Imunohistochemistry
  • Tamoxifen
  • UTROSCT
  • Uterine tumor resembling ovarian sex cord tumor

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