T-bet, pSTAT1 and pSTAT3 expression in peripheral blood mononuclear cells during pregnancy correlates with post-partum activation of multiple sclerosis.

Massimiliano Mirabella, Raffaele Iorio, Giovanni Frisullo, Viviana Nociti, Agata Katia Patanella, Assunta Bianco, Alessandro Marti, Pietro Attilio Tonali, Anna Paola Batocchi

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

In pregnant women affected by multiple sclerosis (MS) we observed increased percentages of CD4(+)CD25(+)Foxp3(+) T regulatory cells at the 1st and the 2nd trimester of gestation that was associated with a decreased T-bet expression in CD4(+) T cells. In women showing clinical relapse and/or new lesions at MRI after delivery we found, a higher expression of T-bet, pSTAT1 and pSTAT3 in CD4(+), CD8(+) T cells and CD14(+) cells, associated with an increase of IFNgamma and IL17 production by PBMC at the 3rd trimester of gestation and after delivery. Our data suggest that the expansion of circulating CD4(+)CD25(+)Foxp3(+) regulatory T cells and the lower expression of T-bet in CD4(+) T cells may account for the decreased MS activity during pregnancy. The expression of T-bet, pSTAT1 and pSTAT3 in peripheral blood CD4(+) and CD8(+) T cells and monocytes could be useful to identify MS patients who will develop a relapse after delivery.
Lingua originaleEnglish
pagine (da-a)70-83
Numero di pagine14
RivistaClinical Immunology
Volume2008
Stato di pubblicazionePubblicato - 2008

Keywords

  • Multiple Sclerosis
  • STAT1
  • STAT3
  • T-bet
  • pregnancy

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