TY - JOUR
T1 - Systemic inflammation markers after simplification to atazanavir/ritonavir plus lamivudine in virologically suppressed HIV-1-infected patients: ATLAS-M substudy
AU - Belmonti, Simone
AU - Lombardi, Francesca
AU - Quiros-Roldan, Eugenia
AU - Latini, Alessandra
AU - Castagna, Antonella
AU - Borghetti, Alberto
AU - Baldin, Gianmaria
AU - Ciccullo, Arturo
AU - Cauda, Roberto
AU - De Luca, Andrea
AU - Di Giambenedetto, Simona
AU - Giacometti, Andrea
AU - Di Pietro, Massimo
AU - Mughini, Maria Teresa
AU - Grima, Pierfrancesco
AU - Viscoli, Claudio
AU - Manconi, Paolo Emilio
AU - Puoti, Massimo
AU - Galli, Massimo
AU - Viale, Pierluigi
AU - Gori, Andrea
AU - Rizzardini, Giuliano
AU - Mineo, Maurizio
AU - Antinori, Andrea
AU - Petrosillo, Nicola
AU - Vullo, Vincenzo
AU - Stella Mura, Maria
AU - Caramello, Pietro
AU - Scotton, Pier Giorgio
AU - Concia, Ercole
AU - Lazzarin, Adriano
AU - Francisci, Daniela
AU - Sacchini, Daria
PY - 2018
Y1 - 2018
N2 - Background
Biomarkers of systemic inflammation predict non-AIDS events and overall mortality in virologically suppressed HIV-1-infected patients.
Objectives
To determine whether switching to a dual antiretroviral maintenance therapy was associated with modification of biomarkers of systemic inflammation as compared with continuation of successful standard triple therapy.
Methods
In this substudy of the randomized ATLAS-M trial, we compared in virologically suppressed patients the impact at 1 year of simplification to a dual therapy with atazanavir/ritonavir plus lamivudine versus maintaining atazanavir/ritonavir plus two NRTI triple therapy on markers of systemic inflammation. Plasma levels of interleukin-6, C-reactive protein (CRP), soluble CD14 (sCD14) and D-dimer were quantified by ELISA at baseline and at 48 weeks.
Results
A subset of 139 of 266 randomized patients with available samples was analysed: 69 in the triple therapy arm and 70 in the dual therapy arm. The baseline biomarker levels were comparable between randomization arms. No significant differences in changes from baseline to week 48 were observed between arms (dual therapy versus triple therapy): IL-6, −0.030 versus −0.016 log10 pg/L; CRP, +0.022 versus +0.027 log10 pg/mL; sCD14, −0.016 versus +0.019 log10 pg/mL; and D-dimer, −0.031 versus +0.004 log10 pg/mL. A history of cancer was associated with higher baseline levels of IL-6 (P = 0.002) and CRP (P = 0.049). No relationship was observed between baseline biomarker level and persistent residual viraemia, HIV-1 DNA load, plasma lipids and other potential explanatory variables.
Conclusions
Simplification with atazanavir/ritonavir plus lamivudine does not affect plasma markers of systemic inflammation in virologically suppressed patients. The association between these findings and clinical outcomes requires further evaluation
AB - Background
Biomarkers of systemic inflammation predict non-AIDS events and overall mortality in virologically suppressed HIV-1-infected patients.
Objectives
To determine whether switching to a dual antiretroviral maintenance therapy was associated with modification of biomarkers of systemic inflammation as compared with continuation of successful standard triple therapy.
Methods
In this substudy of the randomized ATLAS-M trial, we compared in virologically suppressed patients the impact at 1 year of simplification to a dual therapy with atazanavir/ritonavir plus lamivudine versus maintaining atazanavir/ritonavir plus two NRTI triple therapy on markers of systemic inflammation. Plasma levels of interleukin-6, C-reactive protein (CRP), soluble CD14 (sCD14) and D-dimer were quantified by ELISA at baseline and at 48 weeks.
Results
A subset of 139 of 266 randomized patients with available samples was analysed: 69 in the triple therapy arm and 70 in the dual therapy arm. The baseline biomarker levels were comparable between randomization arms. No significant differences in changes from baseline to week 48 were observed between arms (dual therapy versus triple therapy): IL-6, −0.030 versus −0.016 log10 pg/L; CRP, +0.022 versus +0.027 log10 pg/mL; sCD14, −0.016 versus +0.019 log10 pg/mL; and D-dimer, −0.031 versus +0.004 log10 pg/mL. A history of cancer was associated with higher baseline levels of IL-6 (P = 0.002) and CRP (P = 0.049). No relationship was observed between baseline biomarker level and persistent residual viraemia, HIV-1 DNA load, plasma lipids and other potential explanatory variables.
Conclusions
Simplification with atazanavir/ritonavir plus lamivudine does not affect plasma markers of systemic inflammation in virologically suppressed patients. The association between these findings and clinical outcomes requires further evaluation
KW - markers, hiv ,infiammation
KW - markers, hiv ,infiammation
UR - http://hdl.handle.net/10807/119495
U2 - 10.1093/jac/dky125
DO - 10.1093/jac/dky125
M3 - Article
SN - 0305-7453
SP - N/A-N/A
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
ER -