Systemic inflammation markers after simplification to atazanavir/ritonavir plus lamivudine in virologically suppressed HIV-1-infected patients: ATLAS-M substudy

Roberto Cauda, Simona Di Giambenedetto, Simone Belmonti, Francesca Lombardi, Alberto Borghetti, Gianmaria Baldin, Arturo Ciccullo, Andrea De Luca, Eugenia Quiros-Roldan, Alessandra Latini, Antonella Castagna, Andrea Giacometti, Massimo Di Pietro, Maria Teresa Mughini, Pierfrancesco Grima, Claudio Viscoli, Paolo Emilio Manconi, Massimo Puoti, Massimo Galli, Pierluigi VialeAndrea Gori, Giuliano Rizzardini, Maurizio Mineo, Andrea Antinori, Nicola Petrosillo, Vincenzo Vullo, Maria Stella Mura, Pietro Caramello, Pier Giorgio Scotton, Ercole Concia, Adriano Lazzarin, Daniela Francisci, Daria Sacchini

Risultato della ricerca: Contributo in rivistaArticolo in rivista

12 Citazioni (Scopus)

Abstract

Background Biomarkers of systemic inflammation predict non-AIDS events and overall mortality in virologically suppressed HIV-1-infected patients. Objectives To determine whether switching to a dual antiretroviral maintenance therapy was associated with modification of biomarkers of systemic inflammation as compared with continuation of successful standard triple therapy. Methods In this substudy of the randomized ATLAS-M trial, we compared in virologically suppressed patients the impact at 1 year of simplification to a dual therapy with atazanavir/ritonavir plus lamivudine versus maintaining atazanavir/ritonavir plus two NRTI triple therapy on markers of systemic inflammation. Plasma levels of interleukin-6, C-reactive protein (CRP), soluble CD14 (sCD14) and D-dimer were quantified by ELISA at baseline and at 48 weeks. Results A subset of 139 of 266 randomized patients with available samples was analysed: 69 in the triple therapy arm and 70 in the dual therapy arm. The baseline biomarker levels were comparable between randomization arms. No significant differences in changes from baseline to week 48 were observed between arms (dual therapy versus triple therapy): IL-6, −0.030 versus −0.016 log10 pg/L; CRP, +0.022 versus +0.027 log10 pg/mL; sCD14, −0.016 versus +0.019 log10 pg/mL; and D-dimer, −0.031 versus +0.004 log10 pg/mL. A history of cancer was associated with higher baseline levels of IL-6 (P = 0.002) and CRP (P = 0.049). No relationship was observed between baseline biomarker level and persistent residual viraemia, HIV-1 DNA load, plasma lipids and other potential explanatory variables. Conclusions Simplification with atazanavir/ritonavir plus lamivudine does not affect plasma markers of systemic inflammation in virologically suppressed patients. The association between these findings and clinical outcomes requires further evaluation
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaJournal of Antimicrobial Chemotherapy
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • markers, hiv ,infiammation

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