Systemic inflammation-based scores and mortality for all causes in HIV-infected patients: A MASTER cohort study

Simona Di Giambenedetto, Elena Raffetti, Francesco Donato, Salvatore Casari, Filippo Castelnuovo, Laura Sighinolfi, Alessandra Bandera, Franco Maggiolo, Nicoletta Ladisa, Massimo Di Pietro, Chiara Fornabaio, Eugenia Quiros-Roldan

Risultato della ricerca: Contributo in rivistaArticolo in rivista

10 Citazioni (Scopus)

Abstract

Background: Two biomarkers, the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), have been shown to be indicative of systemic inflammation and predictive of mortality in general population. We aimed to assess the association of NLR and PLR, with risk of death in HIV-infected subjects when also taking account of HIV-related factors. Methods: We conducted a multicenter Italian cohort study from 2000 to 2012 including HIV-infected subjects naïve at antiretroviral treatment. The associations of NLR and PLR with all-cause mortality were tested by univariate and multivariate analyses using both time independent and dependent Cox proportional hazard models. We also fitted models with a cubic-spline for PLR and NLR to evaluate the possible non-linear relationship between biomarkers values and risk of death. Results: Eight-thousand and two hundred thirty patients (73.1% males) with a mean age of 38.4 years (SD 10.1) were enrolled. During a median follow-up of 3.9 years, 539 patients died. PLR < 100 and ≥ 200, as compared to PLR of 100-200, and NLR ≥ 2, as compared to < 2, were associated with risk of death at both univariate and multivariate analyses. Using multivariate models with restricted cubic-splines, we found a linear relationship of increasing risk of death with increasing values for NRL over 1.1, and an U-shape curve for PLR, with higher mortality risk for values higher or lower than 120. Conclusions: Our data suggest that NLR and PLR can reflect the severity of the underlying systemic disturbance of the inflammatory process and coagulation leading to augmented mortality in HIV positive subjects.
Lingua originaleEnglish
pagine (da-a)193-193
Numero di pagine1
RivistaBMC Infectious Diseases
Volume17
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Adult
  • Biomarkers
  • Cause of Death
  • Female
  • Follow-Up Studies
  • HIV Infections
  • Humans
  • Infectious Diseases
  • Inflammation
  • Italy
  • Lymphocyte Count
  • Male
  • Middle Aged
  • Mortality for all-causes
  • Neutrophil to lymphocyte ratio
  • Neutrophils
  • Platelet Count
  • Platelet to lymphocyte ratio
  • Proportional Hazards Models
  • Prospective Studies
  • Retrospective Studies

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