@article{05c61b7048e8454dbe528f4163709dfd,
title = "Synthesis of some pyrazole derivatives and preliminary investigation of their affinity binding to P-glycoprotein",
abstract = "A series of substituted pyrazolines were synthesized and evaluated for their anticancer activity and for their ability to inhibit P-glycoprotein-mediated multidrug resistance by direct binding to a purified protein domain containing an ATP-binding site and a modulator interacting region. Compounds 2a and e have been found to bind to P-glycoprotein with greater affinity",
keywords = "P-GLYCOPROTEIN, PYRAZOLE DERIVATES, P-GLYCOPROTEIN, PYRAZOLE DERIVATES",
author = "F Manna and F Chimenti and R Fioravanti and A Bolasco and D Secci and P Chimenti and Cristiano Ferlini and Giovanni Scambia",
year = "2005",
language = "English",
pages = "4632--4635",
journal = "BIOORGANIC & MEDICINAL CHEMISTRY LETTERS",
issn = "0960-894X",
publisher = "Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL:
[email protected],
[email protected], INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010",
}