Synthesis of Polysubstituted 1,2-Dihydro-3H-pyrrolo[1,2-a]indol-3-ones through Domino Palladium-Catalyzed Reactions of Indol-2-ylmethyl Acetates with 1,3-Dicarbonyl Derivatives

Antonia Iazzetti; A Arcadi; S Dessalvi; G Fabrizi; A Goggiamani; F Marrone; A Serraiocco; A Sferrazza; K Ullah

doi:10.3390/catal12121516

Synthesis of Polysubstituted 1,2-Dihydro-3H-pyrrolo[1,2-a]indol-3-ones through Domino Palladium-Catalyzed Reactions of Indol-2-ylmethyl Acetates with 1,3-Dicarbonyl Derivatives

Antonia Iazzetti, A Arcadi, S Dessalvi, G Fabrizi, A Goggiamani^*, F Marrone, A Serraiocco, A Sferrazza^*, K Ullah

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

A straightforward assembly of polysubstituted 1,2-dihydro-3H-pyrrolo[1,2-a]indol-3-ones through a domino palladium-catalyzed reaction of indol-2-ylmethyl acetates with 1,3-dicarbonyl derivatives is described. The key role of the features of the 1,3-dicarbonyls on the reaction outcome has been explored. The employment of 2-methylcyclohexan-1,3-dione as the dicarbonyl source could allow further challenging indole nucleus functionalizations.

Lingua originale	Inglese
pagine (da-a)	1516-1533
Numero di pagine	18
Rivista	Catalysts
Volume	12
Numero di pubblicazione	12
DOI	https://doi.org/10.3390/catal12121516
Stato di pubblicazione	Pubblicato - 2022

All Science Journal Classification (ASJC) codes

Catalisi
Scienze Ambientali Generali
Chimica Fisica e Teorica

Keywords

1
2-a]indol-3-ones
2-dihydro-3H-pyrrolo[1
domino reactions
indolyl methides
palladium catalysis

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10.3390/catal12121516

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Iazzetti, A., Arcadi, A., Dessalvi, S., Fabrizi, G., Goggiamani, A., Marrone, F., Serraiocco, A., Sferrazza, A., & Ullah, K. (2022). Synthesis of Polysubstituted 1,2-Dihydro-3H-pyrrolo[1,2-a]indol-3-ones through Domino Palladium-Catalyzed Reactions of Indol-2-ylmethyl Acetates with 1,3-Dicarbonyl Derivatives. Catalysts, 12(12), 1516-1533. https://doi.org/10.3390/catal12121516

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title = "Synthesis of Polysubstituted 1,2-Dihydro-3H-pyrrolo[1,2-a]indol-3-ones through Domino Palladium-Catalyzed Reactions of Indol-2-ylmethyl Acetates with 1,3-Dicarbonyl Derivatives",

abstract = "A straightforward assembly of polysubstituted 1,2-dihydro-3H-pyrrolo[1,2-a]indol-3-ones through a domino palladium-catalyzed reaction of indol-2-ylmethyl acetates with 1,3-dicarbonyl derivatives is described. The key role of the features of the 1,3-dicarbonyls on the reaction outcome has been explored. The employment of 2-methylcyclohexan-1,3-dione as the dicarbonyl source could allow further challenging indole nucleus functionalizations.",

keywords = "1, 2-a]indol-3-ones, 2-dihydro-3H-pyrrolo[1, domino reactions, indolyl methides, palladium catalysis, 1, 2-a]indol-3-ones, 2-dihydro-3H-pyrrolo[1, domino reactions, indolyl methides, palladium catalysis",

author = "Antonia Iazzetti and A Arcadi and S Dessalvi and G Fabrizi and A Goggiamani and F Marrone and A Serraiocco and A Sferrazza and K Ullah",

year = "2022",

doi = "10.3390/catal12121516",

language = "English",

volume = "12",

pages = "1516--1533",

journal = "Catalysts",

issn = "2073-4344",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "12",

}

Iazzetti, A, Arcadi, A, Dessalvi, S, Fabrizi, G, Goggiamani, A, Marrone, F, Serraiocco, A, Sferrazza, A & Ullah, K 2022, 'Synthesis of Polysubstituted 1,2-Dihydro-3H-pyrrolo[1,2-a]indol-3-ones through Domino Palladium-Catalyzed Reactions of Indol-2-ylmethyl Acetates with 1,3-Dicarbonyl Derivatives', Catalysts, vol. 12, n. 12, pagg. 1516-1533. https://doi.org/10.3390/catal12121516

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T1 - Synthesis of Polysubstituted 1,2-Dihydro-3H-pyrrolo[1,2-a]indol-3-ones through Domino Palladium-Catalyzed Reactions of Indol-2-ylmethyl Acetates with 1,3-Dicarbonyl Derivatives

AU - Iazzetti, Antonia

AU - Arcadi, A

AU - Dessalvi, S

AU - Fabrizi, G

AU - Goggiamani, A

AU - Marrone, F

AU - Serraiocco, A

AU - Sferrazza, A

AU - Ullah, K

PY - 2022

Y1 - 2022

N2 - A straightforward assembly of polysubstituted 1,2-dihydro-3H-pyrrolo[1,2-a]indol-3-ones through a domino palladium-catalyzed reaction of indol-2-ylmethyl acetates with 1,3-dicarbonyl derivatives is described. The key role of the features of the 1,3-dicarbonyls on the reaction outcome has been explored. The employment of 2-methylcyclohexan-1,3-dione as the dicarbonyl source could allow further challenging indole nucleus functionalizations.

AB - A straightforward assembly of polysubstituted 1,2-dihydro-3H-pyrrolo[1,2-a]indol-3-ones through a domino palladium-catalyzed reaction of indol-2-ylmethyl acetates with 1,3-dicarbonyl derivatives is described. The key role of the features of the 1,3-dicarbonyls on the reaction outcome has been explored. The employment of 2-methylcyclohexan-1,3-dione as the dicarbonyl source could allow further challenging indole nucleus functionalizations.

KW - 1

KW - 2-a]indol-3-ones

KW - 2-dihydro-3H-pyrrolo[1

KW - domino reactions

KW - indolyl methides

KW - palladium catalysis

KW - 1

KW - 2-a]indol-3-ones

KW - 2-dihydro-3H-pyrrolo[1

KW - domino reactions

KW - indolyl methides

KW - palladium catalysis

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Synthesis of Polysubstituted 1,2-Dihydro-3H-pyrrolo[1,2-a]indol-3-ones through Domino Palladium-Catalyzed Reactions of Indol-2-ylmethyl Acetates with 1,3-Dicarbonyl Derivatives

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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