Synthesis of Polysubstituted 1,2-Dihydro-3H-pyrrolo[1,2-a]indol-3-ones through Domino Palladium-Catalyzed Reactions of Indol-2-ylmethyl Acetates with 1,3-Dicarbonyl Derivatives

Antonia Iazzetti, Antonio Arcadi, Stefano Dessalvi, Giancarlo Fabrizi, Antonella Goggiamani*, Federico Marrone, Andrea Serraiocco, Alessio Sferrazza*, Karim Ullah

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

A straightforward assembly of polysubstituted 1,2-dihydro-3H-pyrrolo[1,2-a]indol-3-ones through a domino palladium-catalyzed reaction of indol-2-ylmethyl acetates with 1,3-dicarbonyl derivatives is described. The key role of the features of the 1,3-dicarbonyls on the reaction outcome has been explored. The employment of 2-methylcyclohexan-1,3-dione as the dicarbonyl source could allow further challenging indole nucleus functionalizations.
Lingua originaleEnglish
pagine (da-a)1516-1533
Numero di pagine18
RivistaCatalysts
Volume12
DOI
Stato di pubblicazionePubblicato - 2022

Keywords

  • 1,2-dihydro-3H-pyrrolo[1,2-a]indol-3-ones
  • domino reactions
  • indolyl methides
  • palladium catalysis

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