Abstract
A straightforward assembly of polysubstituted 1,2-dihydro-3H-pyrrolo[1,2-a]indol-3-ones through a domino palladium-catalyzed reaction of indol-2-ylmethyl acetates with 1,3-dicarbonyl derivatives is described. The key role of the features of the 1,3-dicarbonyls on the reaction outcome has been explored. The employment of 2-methylcyclohexan-1,3-dione as the dicarbonyl source could allow further challenging indole nucleus functionalizations.
Lingua originale | English |
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pagine (da-a) | 1516-1533 |
Numero di pagine | 18 |
Rivista | Catalysts |
Volume | 12 |
DOI | |
Stato di pubblicazione | Pubblicato - 2022 |
Keywords
- 1,2-dihydro-3H-pyrrolo[1,2-a]indol-3-ones
- domino reactions
- indolyl methides
- palladium catalysis