Synthesis of 4-substituted-1,2-dihydroquinolines by means of gold-catalyzed intramolecular hydroarylation reaction of n-ethoxycarbonyl-n-propargylanilines

Antonia Iazzetti, A. Arcadi, A. Calcaterra, G. Fabrizi, A. Fochetti, A. Goggiamani, F. Marrone, V. Marsicano, G. Mazzoccanti, A. Serraiocco

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

An alternative Au(I)-catalyzed synthetic route to functionalized 1,2-dihydroquinolines is reported. This novel approach is based on the use of N-ethoxycarbonyl protected-Npropargylanilines as building blocks that rapidly undergo the IMHA reaction affording the 6-endo cyclization product in good to high yields. In the presence of N-ethoxycarbonyl-N-propargyl-metasubstituted anilines, the regiodivergent cyclization at the ortho-/para-position is achieved by the means of catalyst fine tuning.
Lingua originaleEnglish
pagine (da-a)3366-3378
Numero di pagine13
RivistaMolecules
Volume26
DOI
Stato di pubblicazionePubblicato - 2021

Keywords

  • 2-dihydroquinolines
  • Gold catalysis
  • intramolecular hydroarylation reaction

Fingerprint

Entra nei temi di ricerca di 'Synthesis of 4-substituted-1,2-dihydroquinolines by means of gold-catalyzed intramolecular hydroarylation reaction of n-ethoxycarbonyl-n-propargylanilines'. Insieme formano una fingerprint unica.

Cita questo