Abstract
The synthesis of 2,3-dihydropyrazino[1,2-a]indol-4(1H)-ones from the sequential reaction of amino acid methyl esters with readily available indole-2-ylmethyl acetates is described. The reaction proceeds in situ under basic conditions of highly unstable and reactive 2-alkylideneindolenines followed by Michael-type addition of a-amino acid methyl esters/intramolecular cyclization.
Lingua originale | English |
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pagine (da-a) | 10090-10096 |
Numero di pagine | 7 |
Rivista | RSC Advances |
Volume | 13 |
DOI | |
Stato di pubblicazione | Pubblicato - 2023 |
Keywords
- reaction