Synthesis of 3-substituted 2,3-dihydropyrazino[1,2- a]indol-4(1H)-ones by sequential reactions of 2- indolylmethyl acetates with a-amino acids

Antonella Goggiamani, Antonio Arcadi, Alessia Ciogli, Martina De Angelis, Stefano Dessalvi, Giancarlo Fabrizi, Federica Iavarone, Antonia Iazzetti, Alessio Sferrazza, Roberta Zoppoli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

The synthesis of 2,3-dihydropyrazino[1,2-a]indol-4(1H)-ones from the sequential reaction of amino acid methyl esters with readily available indole-2-ylmethyl acetates is described. The reaction proceeds in situ under basic conditions of highly unstable and reactive 2-alkylideneindolenines followed by Michael-type addition of a-amino acid methyl esters/intramolecular cyclization.
Lingua originaleEnglish
pagine (da-a)10090-10096
Numero di pagine7
RivistaRSC Advances
Volume13
DOI
Stato di pubblicazionePubblicato - 2023

Keywords

  • reaction

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