Survival after radiotherapy in gastric cancer: systematic review and meta-analysis.

Vincenzo Valentini*, Francesco Cellini, Bd Minsky, Gian Carlo Mattiucci, Mario Balducci, Giuseppe Roberto D'Agostino, Elisa D'Angelo, Nicola Dinapoli, Nicola Nicolotti, Chiara Valentini, Giuseppe La Torre

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo

75 Citazioni (Scopus)

Abstract

A systematic review and meta-analysis was performed to assess the impact of radiotherapy on both 3- and 5-year survival in patients with resectable gastric cancer. METHODS: Randomized Clinical Trials (RCTs) in which radiotherapy, (preoperative, postoperative and/or intraoperative), was compared with surgery alone or surgery plus chemotherapy in resectable gastric cancer were identified by searching web-based databases and supplemented by manual examination of reference lists. Meta-analysis was performed using Risk Ratios (RRs). Random or fixed effects models were used to combine data. The methodological quality was evaluated by Chalmers' score. RESULTS: Radiotherapy had a significant impact on 5-year survival. Using an intent to treat (ITT) and a Per Protocol (PP) analysis, the overall 5-year RR was 1.26 (95% CI: 1.08-1.48; NNT=17) and 1.31 (95% CI: 1.04-1.66; NNT=13), respectively. Although the quality of the studies was variable, the data were consistent and no clear publication bias was found. CONCLUSION: This meta-analysis showed a statistically significant 5-year survival benefit with the addition of radiotherapy in patients with resectable gastric cancer. Radiotherapy remains a standard component in the treatment of resectable gastric cancer and new RCTs need to address the impact of new conformal radiotherapy technologies.
Lingua originaleInglese
pagine (da-a)176-183
RivistaRadiotherapy and Oncology
Volume92
Numero di pubblicazione2
DOI
Stato di pubblicazionePubblicato - 2009

All Science Journal Classification (ASJC) codes

  • Ematologia
  • Oncologia
  • Radiologia, Medicina Nucleare e Diagnostica per Immagini

Keywords

  • GASTRIC CANCER

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