Surfactant protein B and A concentrations are increased in neonatal pneumonia

Sara D'Aronco, Manuela Simonato, Luca Vedovelli, Aldo Baritussio, Giovanna Verlato, Stefano Nobile, Chiara Giorgetti, Matteo Nespeca, Virgilio P. Carnielli, Paola E. Cogo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Background:Term newborns with pneumonia show a reduced pulmonary compliance due to multiple and ill-defined factors. Surfactant proteins' (SPs) changes could have a role in the reduced compliance but the matter is still unsettled. The aim of this study was to clarify the meaning of SPs changes during pneumonia in term newborns.Methods:In 28 term ventilated newborns, 13 with pneumonia and 15 with no lung disease, we measured SP-B, SP-A, disaturated-phosphatidylcholine (DSPC), and total phospholipids (PL) concentrations in tracheal aspirates at intubation and close to extubation. We also measured DSPC kinetics using (U- 13 C-PA)dipalmitoyl-phosphatidylcholine.Results:At baseline, SP-B, expressed as % of PL, was significantly different between the groups, being 3.5-fold higher in pneumonia than controls. Conversely, SP-A did not vary between the groups. At extubation, SP-B and SP-A concentrations had decreased significantly in newborns with pneumonia, while there was no significant change in controls. DSPC t 1/2 was significantly shorter in the pneumonia group (11.8 (5.5-19.8) h vs. 26.6 (19.3-63.6) h, P = 0.011).Conclusion:In term newborns with pneumonia, SP-B increases with respect to PL, and DSPC is turned over at a faster rate. Disease's resolution is associated with the restoration of the normal ratio between SP-B and PL.
Lingua originaleEnglish
pagine (da-a)401-406
Numero di pagine6
RivistaPediatric Research
Volume78
DOI
Stato di pubblicazionePubblicato - 2015
Pubblicato esternamente

Keywords

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