Sulodexide and glycosaminoglycans in the progression of renal disease

Giovanni Gambaro, Valentina Masola, Gianluigi Zaza

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

16 Citazioni (Scopus)

Abstract

Experimental data in cell cultures and animal models suggest that sulodexide and glycosaminoglycans are potentially effective drugs to treat chronic kidney diseases and prevent progression to renal failure. However, no conclusive evidence support the use of them in human renal disease. In acute and chronic glomerulonephritis, only few studies have been performed. Sulodexide has been more intensely investigated in diabetic nephropathy (DN) where the body of data supports its effectiveness as an antialbuminuric agent in early stages. Unfortunately, there is no study in DN patients on the effect of sulodexide on clinical end points.
Lingua originaleEnglish
pagine (da-a)i74-i79
Numero di pagine6
RivistaNephrology Dialysis Transplantation
Volume29
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • FGF-2
  • diabetic nephropathy
  • glycosaminoglycans
  • heparanase-1
  • sulodexide

Fingerprint Entra nei temi di ricerca di 'Sulodexide and glycosaminoglycans in the progression of renal disease'. Insieme formano una fingerprint unica.

Cita questo