Sulodexide and glycosaminoglycans in the progression of renal disease

Valentina Masola, Gianluigi Zaza, Giovanni Gambaro

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

16 Citazioni (Scopus)


Experimental data in cell cultures and animal models suggest that sulodexide and glycosaminoglycans are potentially effective drugs to treat chronic kidney diseases and prevent progression to renal failure. However, no conclusive evidence support the use of them in human renal disease. In acute and chronic glomerulonephritis, only few studies have been performed. Sulodexide has been more intensely investigated in diabetic nephropathy (DN) where the body of data supports its effectiveness as an antialbuminuric agent in early stages. Unfortunately, there is no study in DN patients on the effect of sulodexide on clinical end points.
Lingua originaleEnglish
pagine (da-a)i74-i79
Numero di pagine6
RivistaNephrology Dialysis Transplantation
Stato di pubblicazionePubblicato - 2014


  • FGF-2
  • diabetic nephropathy
  • glycosaminoglycans
  • heparanase-1
  • sulodexide


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