Sudden and isolated Broca's aphasia: a new clinical phenotype of anti NMDA receptor antibodies encephalitis in children

Kumaran Deiva; Maria Carmela Pera; Hélène Maurey; Pascale Chrétien; Frédérique Archambaud; Viviane Bouilleret; Marc Tardieu

doi:10.1016/j.ejpn.2014.06.002

Sudden and isolated Broca's aphasia: a new clinical phenotype of anti NMDA receptor antibodies encephalitis in children

Kumaran Deiva, Maria Carmela Pera, Hélène Maurey, Pascale Chrétien, Frédérique Archambaud, Viviane Bouilleret, Marc Tardieu

Assistance publique – Hôpitaux de Paris

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Background: Anti NMDA receptor (anti NMDAR) encephalitis is a well-characterized entity in children associating movement disorders, psychiatric features and speech difficulties. Novel phenotypes have been described in adults.Methods and Results: A 4-year-old girl presented partial seizures which evolved towards sudden and isolated Broca's aphasia. Anti NMDAR antibodies were positive in CSF and serum confirming anti NMDAR encephalitis. Clinical recovery was observed after a specific treatment.Conclusion: This case widens the clinical spectrum of anti-NMDAR encephalitis in children and awareness of this newly identified symptom is important as early treatment is a predictor of good outcome (C) 2014 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

Lingua originale	English
pagine (da-a)	790-792
Numero di pagine	3
Rivista	European Journal of Paediatric Neurology
Volume	18
DOI	https://doi.org/10.1016/j.ejpn.2014.06.002
Stato di pubblicazione	Pubblicato - 2014

Keywords

Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Aphasia, Broca
Auto immune
Broca's aphasia
Child
Children
Electroencephalography
Epilepsy
Female
Fluorodeoxyglucose F18
Humans
NMDAR encephalitis
Positron-Emission Tomography
Receptors, N-Methyl-D-Aspartate

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10.1016/j.ejpn.2014.06.002

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title = "Sudden and isolated Broca's aphasia: a new clinical phenotype of anti NMDA receptor antibodies encephalitis in children",

abstract = "Background: Anti NMDA receptor (anti NMDAR) encephalitis is a well-characterized entity in children associating movement disorders, psychiatric features and speech difficulties. Novel phenotypes have been described in adults.Methods and Results: A 4-year-old girl presented partial seizures which evolved towards sudden and isolated Broca's aphasia. Anti NMDAR antibodies were positive in CSF and serum confirming anti NMDAR encephalitis. Clinical recovery was observed after a specific treatment.Conclusion: This case widens the clinical spectrum of anti-NMDAR encephalitis in children and awareness of this newly identified symptom is important as early treatment is a predictor of good outcome (C) 2014 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.",

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author = "Kumaran Deiva and Pera, {Maria Carmela} and H{\'e}l{\`e}ne Maurey and Pascale Chr{\'e}tien and Fr{\'e}d{\'e}rique Archambaud and Viviane Bouilleret and Marc Tardieu",

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language = "English",

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T1 - Sudden and isolated Broca's aphasia: a new clinical phenotype of anti NMDA receptor antibodies encephalitis in children

AU - Deiva, Kumaran

AU - Pera, Maria Carmela

AU - Maurey, Hélène

AU - Chrétien, Pascale

AU - Archambaud, Frédérique

AU - Bouilleret, Viviane

AU - Tardieu, Marc

PY - 2014

Y1 - 2014

N2 - Background: Anti NMDA receptor (anti NMDAR) encephalitis is a well-characterized entity in children associating movement disorders, psychiatric features and speech difficulties. Novel phenotypes have been described in adults.Methods and Results: A 4-year-old girl presented partial seizures which evolved towards sudden and isolated Broca's aphasia. Anti NMDAR antibodies were positive in CSF and serum confirming anti NMDAR encephalitis. Clinical recovery was observed after a specific treatment.Conclusion: This case widens the clinical spectrum of anti-NMDAR encephalitis in children and awareness of this newly identified symptom is important as early treatment is a predictor of good outcome (C) 2014 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

AB - Background: Anti NMDA receptor (anti NMDAR) encephalitis is a well-characterized entity in children associating movement disorders, psychiatric features and speech difficulties. Novel phenotypes have been described in adults.Methods and Results: A 4-year-old girl presented partial seizures which evolved towards sudden and isolated Broca's aphasia. Anti NMDAR antibodies were positive in CSF and serum confirming anti NMDAR encephalitis. Clinical recovery was observed after a specific treatment.Conclusion: This case widens the clinical spectrum of anti-NMDAR encephalitis in children and awareness of this newly identified symptom is important as early treatment is a predictor of good outcome (C) 2014 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

KW - Anti-N-Methyl-D-Aspartate Receptor Encephalitis

KW - Aphasia, Broca

KW - Auto immune

KW - Broca's aphasia

KW - Child

KW - Children

KW - Electroencephalography

KW - Epilepsy

KW - Female

KW - Fluorodeoxyglucose F18

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KW - NMDAR encephalitis

KW - Positron-Emission Tomography

KW - Receptors, N-Methyl-D-Aspartate

KW - Anti-N-Methyl-D-Aspartate Receptor Encephalitis

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KW - Auto immune

KW - Broca's aphasia

KW - Child

KW - Children

KW - Electroencephalography

KW - Epilepsy

KW - Female

KW - Fluorodeoxyglucose F18

KW - Humans

KW - NMDAR encephalitis

KW - Positron-Emission Tomography

KW - Receptors, N-Methyl-D-Aspartate

UR - http://hdl.handle.net/10807/213570

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JO - European Journal of Paediatric Neurology

JF - European Journal of Paediatric Neurology

ER -

Sudden and isolated Broca's aphasia: a new clinical phenotype of anti NMDA receptor antibodies encephalitis in children

Abstract

Keywords

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