Successful use of extended criteria donor grafts with low to moderate steatosis in patients with model for end-stage liver disease scores below 27

Alfonso Wolfango Avolio, Salvatore Agnes, Francesco Frongillo, Nicola Nicolotti, A Mulè, G Vennarecci, P De Simone

Risultato della ricerca: Contributo in rivistaArticolo in rivista

15 Citazioni (Scopus)

Abstract

Liver transplantation may be performed using extended criteria donor grafts (ECDg). The characteristics of ECDg include age >60 years, long intensive care unit (ICU) stay, history of malignancy or steatosis. Grafts are often discarded due to steatosis, which can be macrovesicular (MaS) or microvesicular (MiS). MaS is the variety most frequently involved with unfavorable outcomes due to primary nonfunction (PNF) or primary dysfunction (PDF). As of January 2000, all livers referred to our institution were considered potentially transplantable. Steatosis was defined as the presence of fat droplets in more than 5% of hepatocytes. We observed 35 steatotic grafts. Grafts were stratified according to MaS and MiS as follows: low steatosis (5%-15%), mild steatosis (16%-30%), moderate steatosis (31%-60%), or severe steatosis (>60%). Fifteen grafts with moderate (n = 2) or severe (n = 13) MaS were discarded. Twenty grafts were harvested: 18 of them were transplanted at our institution, the remaining 2, discarded by our donor team, were transplanted by other Italian centers. Low MaS was detected in 10 grafts (50%), mild MaS in 4 (20%), and moderate MaS in 2 (10%). Low MiS was detected in 8 grafts (40%), mild MiS in 5 (25%), and moderate MiS in 1 (5%). Steatotic grafts were transplanted only into recipients with model for end-stage liver disease (MELD) scores <27. The 6-month graft survival was 80%; the PNF rate was 10%; and the PDF rate was 15%. The careful use of ECDg with low to moderate steatosis is possible if particular care is taken to avoid additional risk factors related to the recipient.
Lingua originaleEnglish
pagine (da-a)208-212
Numero di pagine5
RivistaTransplantation Proceedings
Volume41
DOI
Stato di pubblicazionePubblicato - 2009

Keywords

  • Adult
  • Biopsy
  • Fatty Liver
  • Graft Survival
  • Humans
  • Life Tables
  • Liver Failure
  • Liver Failure, Acute
  • Liver Transplantation
  • Middle Aged
  • Patient Selection
  • Reoperation
  • Tissue Donors
  • Young Adult

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