Successful pregnancy and breastfeeding in a woman with mucopolysaccharidosis type I while receiving laronidase enzyme replacement. therapy

Mario N Castorina, Daniela Antuzzi, S. M. Richards, G. F. Cox, Y. Xue

Risultato della ricerca: Contributo in rivistaArticolo in rivista

11 Citazioni (Scopus)

Abstract

The authors describe the first mother-infant pair to complete an on-going, prospective, open-label, Phase 4 trial (ALIU) UU3, NCT00418821) determining the safety of laronidase enzyme replacement therapy (ERT) in pregnant women with mucopolysaccharidosis type I (MPS I) and their breastfed infants. The mother, a 32-year-old with attenuated MPS I (Scheie syndrome), received laronidase for three years and continued treatment throughout her second pregnancy and while lactating. A healthy 2.5 kg male was delivered by elective cesarean section at 37 weeks. He was breastfed for three months. No laronidase was detected in breast milk. The infant never developed anti-laronidase IgM antibodies, never had inhibitory antibody activity in a cellular uptake assay, and always had normal urinary glycosaminoglycan (GAG) levels. No drug-related adverse events were reported. At 2.5 years of age, the boy is healthy with normal growth and development. In this first prospectively monitored mother-infant pair, laronidase during pregnancy and breastfeeding was uneventful.
Lingua originaleEnglish
pagine (da-a)108-113
Numero di pagine6
RivistaCLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
Volume42
Stato di pubblicazionePubblicato - 2015

Keywords

  • Adult
  • Breast Feeding
  • Drug Monitoring
  • Enzyme Replacement Therapy
  • Female
  • Glycosaminoglycans
  • Humans
  • Iduronidase
  • Infant, Newborn
  • Male
  • Milk, Human
  • Monitoring, Immunologic
  • Mucopolysaccharidosis I
  • Pregnancy
  • Pregnancy Complications
  • Pregnancy Outcome
  • Prospective Studies

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