Subclinical epileptiform activity during sleep in Alzheimer's disease and mild cognitive impairment

Giacomo Della Marca, Camillo Marra, Catello Vollono, Maria Gabriella Vita, Paolo Maria Rossini, Aurora D'Atri

Risultato della ricerca: Contributo in rivistaArticolo in rivista

4 Citazioni (Scopus)


Objective: Recent findings suggested that subclinical epileptiform activity is prevalent during sleep in a significant proportion of Alzheimer's Disease (AD) patients. The aims of our study were: (A) comparing the frequency of subclinical epileptiform activity during the sleep in a sample diagnosed with ‘probable’ AD and Mild Cognitive Impairment (MCI) due to AD, and in healthy subjects; (B) evaluating epileptiform EEG activity as a function of different sleep stages within a well-controlled polysomnographic setting. Methods: We prospectively enrolled 50 ‘probable’ AD patients (73 ± 7.0 years) and 50 subjects with MCI due to AD (72 ± 6.7 years) without history of seizures, comparing them with 50 controls (69 ± 6.7 years). Patients underwent to a full-night video-PSG. Results: Subclinical epileptiform activity was detected in 6.38% of ‘probable’ AD patients, 11.63% of MCI due to AD subjects and 4.54% of controls (p = 0.43). The comparisons between the three groups for the frequency of epileptiform activity did not reach statistically significant differences neither for total sleep nor for any sleep period considered. Conclusions: Our study shows that, when controlling for sleep stages and the influence of psychoactive drugs, AD patients and MCI due to AD subjects do not exhibit a higher frequency of epileptiform discharges during sleep compared to healthy subjects. Significance: Subclinical epileptiform activity during sleep does not discriminate ‘probable’ AD from MCI due to AD and healthy controls.
Lingua originaleEnglish
pagine (da-a)1011-1018
Numero di pagine8
RivistaClinical Neurophysiology
Stato di pubblicazionePubblicato - 2020


  • Alzheimer's Disease
  • Epilepsy
  • Mild Cognitive Impairment
  • Sleep
  • Subclinical Epileptiform Activity


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