Subarachnoid hemorrhage during sexual activity after sildenafil intake: an accidental association?

Fabio De Giorgio, Vincenzo Arena, Elisa Arena, Maria Lodise, Ernesto D'Aloja, Marcello Chiarotti, Luca Valerio

Risultato della ricerca: Contributo in rivistaArticolo in rivista

7 Citazioni (Scopus)

Abstract

We report and describe an autopsy case of a man dead for rupture of cerebral artery aneurysm with subsequent subarachnoid hemorrhage after sexual intercourse. Toxicologic analysis demonstrated that he had consumed sildenafil (Viagra). Although subarachnoid hemorrhage has been reported to be associated with sexual intercourse, it is not among the known adverse effects of sildenafil. However, sildenafil has been found to interact with vascular physiology via multiple mechanisms and in most of the vascular districts of the human body. This case provides an example of a very rare association between this drug and a fatal pathologic event and deserves to be added to the existing clinical knowledge about sildenafil and the pathophysiology of the events involved. This knowledge may be helpful in orienting further investigation into the mechanisms of action of sildenafil and their clinical implications.
Lingua originaleEnglish
pagine (da-a)310-311
Numero di pagine2
RivistaTHE AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY
Volume2011
Stato di pubblicazionePubblicato - 2011

Keywords

  • sildenafil
  • subarachnoid hemorrhage

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