Abstract
Carnitine deficiency can be associated with cardiomyopathy and life-threatening
arrhythmias. The aim of this study was to assess changes of ventricular repolarization (VR)
intervals by contactless magnetocardiographic mapping (MCG), in a rat model of carnitine
deficiency. 21 anesthetized Wistar rats (WR), 11 males and 10 females, were investigated, with an
unshielded 36-channel MCG instrumentation. After a basal recording 10 animals were randomized
to carnitine-deprivation induced by a 3-weeks diet containing N-trimethyl-hydrazine-3-propionate
(THP). All WR were restudied 1 week after the end of THP treatment. RR, QRS, QTpeak, QTend,
JTpeak, JTend and Tpeak-end intervals were measured from MCG waveforms. A prolongation of all HRcorrected
VR intervals was observed in THP-treated animals (range 7.6–12.8%), as compared to
their basal values. However, only the lengthening of QTend and Tpeak-end was statistically significant
(pb0.05). Compared to untreated age-matched controls, the cardiac intervals of TPH-treated WR
values were longer, but the differences were not significant. After 3 weeks of THP-induced reduction
of cardiac and plasma levels of carnitine, abnormalities in myocardial function are expected. In this
study we have found only a prolongation of HR-corrected QTend and Tpeak-end in THP-treated
animals. The lack of significance versus age-matched controls could be either due to too early reevaluation
after deprivation, or to the effect of aging. In fact, age-related prolongation of VR
intervals has been reported in WR at the age of 14 months
Lingua originale | English |
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Titolo della pubblicazione ospite | Int. Congr. Ser. |
Pagine | 455-458 |
Numero di pagine | 4 |
Stato di pubblicazione | Pubblicato - 2007 |
Pubblicato esternamente | Sì |
Evento | 15th International Conference on Biomagnetism, Biomag 2006 - Vancouver Durata: 20 ago 2006 → 26 ago 2006 |
Convegno
Convegno | 15th International Conference on Biomagnetism, Biomag 2006 |
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Città | Vancouver |
Periodo | 20/8/06 → 26/8/06 |
Keywords
- carnitine
- magnetocardiography
- wistar rat