Study of ventricular repolarization changes after carnitine deprivation in rats by contactless magnetocardiography.

Donatella Brisinda, V. Giordano, M. Calvani, Riccardo Fenici

Risultato della ricerca: Contributo in libroContributo a convegno


Carnitine deficiency can be associated with cardiomyopathy and life-threatening 7 arrhythmias. The aim of this study was to assess changes of ventricular repolarization (VR) 8 intervals by contactless magnetocardiographic mapping (MCG), in a rat model of carnitine 9 deficiency. 21 anesthetized Wistar rats (WR), 11 males and 10 females, were investigated, with an 10 unshielded 36-channel MCG instrumentation. After a basal recording 10 animals were randomized 11 to carnitine-deprivation induced by a 3-weeks diet containing N-trimethyl-hydrazine-3-propionate 12 (THP). All WR were restudied 1 week after the end of THP treatment. RR, QRS, QTpeak, QTend, 13 JTpeak, JTend and Tpeak-end intervals were measured from MCG waveforms. A prolongation of all HR- 14 corrected VR intervals was observed in THP-treated animals (range 7.6 12.8%), as compared to 15 their basal values. However, only the lengthening of QTend and Tpeak-end was statistically significant 16 (pb0.05). Compared to untreated age-matched controls, the cardiac intervals of TPH-treated WR 17 values were longer, but the differences were not significant. After 3 weeks of THP-induced reduction 18 of cardiac and plasma levels of carnitine, abnormalities in myocardial function are expected. In this 19 study we have found only a prolongation of HR-corrected QTend and Tpeak-end in THP-treated 20 animals. The lack of significance versus age-matched controls could be either due to too early re- 21 evaluation after deprivation, or to the effect of aging. In fact, age-related prolongation of VR 22 intervals has been reported in WR at the age of 14 months.
Lingua originaleEnglish
Titolo della pubblicazione ospiteProceedings of the XV International Conference on biomagnetism (International Congress Series)
Numero di pagine1
Stato di pubblicazionePubblicato - 2006
Pubblicato esternamente
EventoXV international Conference on Biomagnetism - Vancouver
Durata: 20 ago 200626 ago 2006


ConvegnoXV international Conference on Biomagnetism




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