The tablet PC represents a very popular mobile computing device, and together with other technologies it is changing the world of education. This study aimed to explore the acceptance of tablet PC of Italian high school students in order to outline the typical students' profiles and to compare the acceptance conveyed in two types of use (learning and communicative activities at school). Data were collected using an online survey that was filled out by students at home. Two hundred and ninety-six students from six public high schools in Milan and surrounding suburbs voluntarily accepted to participate in the study. The results show a varied situation in the Italian schools despite the availability of and funding for the technology. Three clusters were identified with high, moderate and low acceptance of tablet PC and a comparison between such clusters revealed significant differences in gender, grade level and usage frequency. The groups showed also significant differences in relation to the uses of tablet PC at school that appeared coherent with their level of acceptance: students who have higher level of acceptance are those who use the tool more both for learning and communicative purposes. To conclude, students with lower acceptance probably need to better understand the opportunities offered by this technology and how to use it. Based on examining the data from the survey, preliminary recommendations are made.