Strong YB-1 expression predicts liver recurrence following resection for colorectal metastases

Introduction The Y-box binding protein-1 (YB-1) is a multifunctional oncoprotein involved in the proliferation and aggressiveness\r\nof cancer cells. The aim of this study was to determine whether strong YB-1 expression in neoplastic cells of colorectal liver\r\nmetastases (CRLM) may have an impact on liver disease-free survival following liver resection.\r\nMaterials and Methods Immunohistochemistry was performed to evaluate YB-1 in 66 patients who underwent liver resection for\r\nCRLM. YB-1 expression was classified as weak (low-staining intensity) and strong (high-staining intensity).\r\nResults YB-1 expression was observed in the cytoplasm of all CRLM. YB-1 expression was weak in 17 patients (25.8 %) and\r\nstrong in 49 patients (74.2 %). Liver recurrence rate was significantly higher in the strong than in the weak expression group: 55.1\r\nvs. 23.5%(p=0.023).Multivariable logistic regression analysis showed that YB-1 strong expression was the only independent risk\r\nfactor for liver recurrence. The 5-year specific liver disease-free survival rate was 76.0 % in the weak expression group and 41.5 %\r\nin the strong expression group (p=0.034). These results were not influenced by clinical prognostic factors of tumor recurrence.\r\nConclusions This is the first study showing that the degree of YB-1 expression in tissue specimens of CRLM predicts liver\r\nrecurrence following liver resection