Strong YB-1 expression predicts liver recurrence following resection for colorectal metastases

Francesco Ardito, Vincenzo Arena, Maria Vellone, Gennaro Nuzzo, Felice Giuliante, Ilaria Pennacchia, Ivo Giovannini, Fabio Maria Vecchio

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

5 Citazioni (Scopus)

Abstract

Introduction The Y-box binding protein-1 (YB-1) is a multifunctional oncoprotein involved in the proliferation and aggressiveness of cancer cells. The aim of this study was to determine whether strong YB-1 expression in neoplastic cells of colorectal liver metastases (CRLM) may have an impact on liver disease-free survival following liver resection. Materials and Methods Immunohistochemistry was performed to evaluate YB-1 in 66 patients who underwent liver resection for CRLM. YB-1 expression was classified as weak (low-staining intensity) and strong (high-staining intensity). Results YB-1 expression was observed in the cytoplasm of all CRLM. YB-1 expression was weak in 17 patients (25.8 %) and strong in 49 patients (74.2 %). Liver recurrence rate was significantly higher in the strong than in the weak expression group: 55.1 vs. 23.5%(p=0.023).Multivariable logistic regression analysis showed that YB-1 strong expression was the only independent risk factor for liver recurrence. The 5-year specific liver disease-free survival rate was 76.0 % in the weak expression group and 41.5 % in the strong expression group (p=0.034). These results were not influenced by clinical prognostic factors of tumor recurrence. Conclusions This is the first study showing that the degree of YB-1 expression in tissue specimens of CRLM predicts liver recurrence following liver resection
Lingua originaleEnglish
pagine (da-a)1987-1993
Numero di pagine7
RivistaJournal of Gastrointestinal Surgery
Volume18
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • Colorectal liver metastases
  • Liver recurrence
  • Liver resection
  • Molecular markers
  • YB-1

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