TY - JOUR
T1 - Stromal circuits involving tumor-associated macrophages and cancer-associated fibroblasts
AU - Timperi, Eleonora
AU - Romano, Emanuela
PY - 2023
Y1 - 2023
N2 - The tumor associated macrophages (TAM) represent one of most abundant subpopulations across several solid cancers and their number/frequency is associated with a poor clinical outcome. It has been clearly demonstrated that stromal cells, such as the cancer associated fibroblasts (CAFs), may orchestrate TAM recruitment, survival and reprogramming. Today, single cell-RNA sequencing (sc-RNA seq) technologies allowed a more granular knowledge about TAMs and CAFs phenotypical and functional programs. In this mini-review we discuss the recent discoveries in the sc-RNA seq field focusing on TAM and CAF identity and their crosstalk in the tumor microenvironment (TME) of solid cancers.
AB - The tumor associated macrophages (TAM) represent one of most abundant subpopulations across several solid cancers and their number/frequency is associated with a poor clinical outcome. It has been clearly demonstrated that stromal cells, such as the cancer associated fibroblasts (CAFs), may orchestrate TAM recruitment, survival and reprogramming. Today, single cell-RNA sequencing (sc-RNA seq) technologies allowed a more granular knowledge about TAMs and CAFs phenotypical and functional programs. In this mini-review we discuss the recent discoveries in the sc-RNA seq field focusing on TAM and CAF identity and their crosstalk in the tumor microenvironment (TME) of solid cancers.
KW - cancer associated fibroblasts (CAF)
KW - monocytes
KW - tumor associated macrophages (TAM)
KW - solid tumors
KW - single cell RNA analysis
KW - cancer associated fibroblasts (CAF)
KW - monocytes
KW - tumor associated macrophages (TAM)
KW - solid tumors
KW - single cell RNA analysis
UR - http://hdl.handle.net/10807/305306
U2 - 10.3389/fimmu.2023.1194642
DO - 10.3389/fimmu.2023.1194642
M3 - Article
SN - 1664-3224
VL - 14
SP - N/A-N/A
JO - Frontiers in Immunology
JF - Frontiers in Immunology
ER -