Stromal circuits involving tumor-associated macrophages and cancer-associated fibroblasts

Eleonora Timperi, Emanuela Romano

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

The tumor associated macrophages (TAM) represent one of most abundant subpopulations across several solid cancers and their number/frequency is associated with a poor clinical outcome. It has been clearly demonstrated that stromal cells, such as the cancer associated fibroblasts (CAFs), may orchestrate TAM recruitment, survival and reprogramming. Today, single cell-RNA sequencing (sc-RNA seq) technologies allowed a more granular knowledge about TAMs and CAFs phenotypical and functional programs. In this mini-review we discuss the recent discoveries in the sc-RNA seq field focusing on TAM and CAF identity and their crosstalk in the tumor microenvironment (TME) of solid cancers.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaFrontiers in Immunology
Volume14
DOI
Stato di pubblicazionePubblicato - 2023

Keywords

  • cancer associated fibroblasts (CAF)
  • monocytes
  • tumor associated macrophages (TAM)
  • solid tumors
  • single cell RNA analysis

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