Stroke and COVID19: Not only a large-vessel disease

Giovanni Frisullo, Simone Bellavia, Irene Scala, Carla Piano, Roberta Morosetti, Valerio Brunetti, Paolo Calabresi, Giacomo Della Marca

Risultato della ricerca: Contributo in rivistaArticolo in rivista

6 Citazioni (Scopus)


Recent evidence has underlined the association between large-vessel stroke and COVID-19, probably due to a proinflammatory and prothrombotic microenvironment induced by SARS-CoV-2. Here, we report the case of a young fit woman affected by COVID-19 without any flu-like symptom, who suffered from speech disorder and left hemiparesis. Brain magnetic resonance evidenced two small acute brain infarctions in right perirolandic cortex without signs of previous ischemic lesions and hemorrhagic infarction. Diagnostic workup excluded cardiac embolic sources, acquired and inherited thrombophilia or autoimmune diseases. Two positive nasopharyngeal swab tests and high titers of serum specific IgA/IgM confirmed COVID-19 diagnosis. In our case stroke seems to be the only manifestation of SARS-COV-2 infection. Therefore the hypothesis of an underlying viral infection, as COVID-19, should be investigated in all the cases of small vessel cryptogenic stroke.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaJournal of Stroke and Cerebrovascular Diseases
Stato di pubblicazionePubblicato - 2020


  • Betacoronavirus
  • COVID-19
  • COVID19
  • Cerebral Small Vessel Diseases
  • Coronavirus Infections
  • Female
  • Host Microbial Interactions
  • Humans
  • Middle Aged
  • Nursing Staff, Hospital
  • Pandemics
  • Paresis
  • Pneumonia, Viral
  • Risk Factors
  • SARS-COV-2
  • SARS-CoV-2
  • Small-vessel occlusion
  • Speech Disorders
  • Stroke


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