Steroid treatment of acute graft-versus-host disease grade I: A randomized trial

Andrea Bacigalupo; Giuseppe Milone; Alessandra Cupri; Antonio Severino; Franca Fagioli; Massimo Berger; Stella Santarone; Patrizia Chiusolo; Simona Sica; Sonia Mammoliti; Roberto Sorasio; Daniela Massi; Maria Teresa Van Lint; Anna Maria Raiola; Francesca Gualandi; Carmine Selleri; Maria Pia Sormani; Alessio Signori; Antonio Risitano; Francesca Bonifazi

doi:10.3324/haematol.2017.171157

Steroid treatment of acute graft-versus-host disease grade I: A randomized trial

Andrea Bacigalupo, Giuseppe Milone, Alessandra Cupri, Antonio Severino, Franca Fagioli, Massimo Berger, Stella Santarone, Patrizia Chiusolo, Simona Sica, Sonia Mammoliti, Roberto Sorasio, Daniela Massi, Maria Teresa Van Lint, Anna Maria Raiola, Francesca Gualandi, Carmine Selleri, Maria Pia Sormani, Alessio Signori, Antonio Risitano, Francesca Bonifazi

Risultato della ricerca: Contributo in rivista › Articolo in rivista

8 Citazioni (Scopus)

Abstract

Patients with acute graft-versus-host disease (GvHD) grade I were randomized to an observation arm (n=85) or to a treatment arm (n=86) consisting of 6-methylprednisolone 1 mg/kg/day, after stratification for age and donor type. The primary end point was development of grade II-IV GvHD. The cumulative incidence of grade II-IV GvHD was 50% in the observation arm and 33% in the treatment arm (P=0.005). However, grade III-IV GvHD was comparable (13% vs. 10%, respectively; P=0.6), and this was true for sibling and alternative donor transplants. Moderate/severe chronic GvHD was also comparable (17% vs. 9%). In multivariate analysis, an early interval between transplant and randomization (

Lingua originale	English
pagine (da-a)	2125-2133
Numero di pagine	9
Rivista	Haematologica
Volume	102
DOI	https://doi.org/10.3324/haematol.2017.171157
Stato di pubblicazione	Pubblicato - 2017

Keywords

Hematology

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10.3324/haematol.2017.171157

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Bacigalupo, A., Milone, G., Cupri, A., Severino, A., Fagioli, F., Berger, M., Santarone, S., Chiusolo, P., Sica, S., Mammoliti, S., Sorasio, R., Massi, D., Van Lint, M. T., Raiola, A. M., Gualandi, F., Selleri, C., Sormani, M. P., Signori, A., Risitano, A., & Bonifazi, F. (2017). Steroid treatment of acute graft-versus-host disease grade I: A randomized trial. Haematologica, 102, 2125-2133. https://doi.org/10.3324/haematol.2017.171157

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title = "Steroid treatment of acute graft-versus-host disease grade I: A randomized trial",

abstract = "Patients with acute graft-versus-host disease (GvHD) grade I were randomized to an observation arm (n=85) or to a treatment arm (n=86) consisting of 6-methylprednisolone 1 mg/kg/day, after stratification for age and donor type. The primary end point was development of grade II-IV GvHD. The cumulative incidence of grade II-IV GvHD was 50% in the observation arm and 33% in the treatment arm (P=0.005). However, grade III-IV GvHD was comparable (13% vs. 10%, respectively; P=0.6), and this was true for sibling and alternative donor transplants. Moderate/severe chronic GvHD was also comparable (17% vs. 9%). In multivariate analysis, an early interval between transplant and randomization (",

keywords = "Hematology, Hematology",

author = "Andrea Bacigalupo and Giuseppe Milone and Alessandra Cupri and Antonio Severino and Franca Fagioli and Massimo Berger and Stella Santarone and Patrizia Chiusolo and Simona Sica and Sonia Mammoliti and Roberto Sorasio and Daniela Massi and {Van Lint}, {Maria Teresa} and Raiola, {Anna Maria} and Francesca Gualandi and Carmine Selleri and Sormani, {Maria Pia} and Alessio Signori and Antonio Risitano and Francesca Bonifazi",

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doi = "10.3324/haematol.2017.171157",

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Bacigalupo, A, Milone, G, Cupri, A, Severino, A, Fagioli, F, Berger, M, Santarone, S, Chiusolo, P , Sica, S, Mammoliti, S, Sorasio, R, Massi, D, Van Lint, MT, Raiola, AM, Gualandi, F, Selleri, C, Sormani, MP, Signori, A, Risitano, A & Bonifazi, F 2017, 'Steroid treatment of acute graft-versus-host disease grade I: A randomized trial', Haematologica, vol. 102, pagg. 2125-2133. https://doi.org/10.3324/haematol.2017.171157

TY - JOUR

T1 - Steroid treatment of acute graft-versus-host disease grade I: A randomized trial

AU - Bacigalupo, Andrea

AU - Milone, Giuseppe

AU - Cupri, Alessandra

AU - Severino, Antonio

AU - Fagioli, Franca

AU - Berger, Massimo

AU - Santarone, Stella

AU - Chiusolo, Patrizia

AU - Sica, Simona

AU - Mammoliti, Sonia

AU - Sorasio, Roberto

AU - Massi, Daniela

AU - Van Lint, Maria Teresa

AU - Raiola, Anna Maria

AU - Gualandi, Francesca

AU - Selleri, Carmine

AU - Sormani, Maria Pia

AU - Signori, Alessio

AU - Risitano, Antonio

AU - Bonifazi, Francesca

PY - 2017

Y1 - 2017

N2 - Patients with acute graft-versus-host disease (GvHD) grade I were randomized to an observation arm (n=85) or to a treatment arm (n=86) consisting of 6-methylprednisolone 1 mg/kg/day, after stratification for age and donor type. The primary end point was development of grade II-IV GvHD. The cumulative incidence of grade II-IV GvHD was 50% in the observation arm and 33% in the treatment arm (P=0.005). However, grade III-IV GvHD was comparable (13% vs. 10%, respectively; P=0.6), and this was true for sibling and alternative donor transplants. Moderate/severe chronic GvHD was also comparable (17% vs. 9%). In multivariate analysis, an early interval between transplant and randomization (

AB - Patients with acute graft-versus-host disease (GvHD) grade I were randomized to an observation arm (n=85) or to a treatment arm (n=86) consisting of 6-methylprednisolone 1 mg/kg/day, after stratification for age and donor type. The primary end point was development of grade II-IV GvHD. The cumulative incidence of grade II-IV GvHD was 50% in the observation arm and 33% in the treatment arm (P=0.005). However, grade III-IV GvHD was comparable (13% vs. 10%, respectively; P=0.6), and this was true for sibling and alternative donor transplants. Moderate/severe chronic GvHD was also comparable (17% vs. 9%). In multivariate analysis, an early interval between transplant and randomization (

KW - Hematology

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UR - http://www.haematologica.org/content/haematol/102/12/2125.full.pdf

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DO - 10.3324/haematol.2017.171157

M3 - Article

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VL - 102

SP - 2125

EP - 2133

JO - Haematologica

JF - Haematologica

ER -

Steroid treatment of acute graft-versus-host disease grade I: A randomized trial

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